叶酸辅助治疗对H型高血压患者血浆同型半胱氨酸和血压水平的影响  

Effects of Folic Acid on Plasma Homocysteine and Blood Pressure in Patients with Type H Hypertension

作　　者：陆少锋[1] 梁剑梅[1] 李秀华[1] 赵冠耀[1] 

机构地区：[1]佛山市高明区人民医院,广东佛山528500

出　　处：《中国药房》2013年第8期716-718,共3页China Pharmacy

摘　　要：目的:观察叶酸辅助治疗对H型高血压患者血浆同型半胱氨酸(Hcy)和血压水平的影响。方法:将我院176例H型高血压患者随机分为试验组(83例)和对照组(93例),两组患者均给予常规降压药物治疗,试验组同时口服叶酸5mg,每日1次。两组疗程均为6个月。观察两组患者治疗前及治疗6个月后血浆Hcy水平和动态血压水平的变化,并观察不良反应情况。结果:与治疗前及对照组患者比较,试验组患者治疗6个月后血浆Hcy水平显著下降(P<0.05);试验组及对照组患者治疗6个月后血压水平均较治疗前显著下降(P<0.05),而组间比较差异无统计学意义(P>0.05),但试验组非杓型血压发生率较对照组显著下降(P<0.05)。两组均未见明显不良反应发生。结论:叶酸治疗可以降低H型高血压患者血浆Hcy水平,降低非杓型血压发生率。OBJECTIVE： To investigate the effect of folic acid on plasma homocysteine （Hcy） and blood pressure in patients with type H hypertension. METHODS： 176 patients with type H hypertension were randomized into trial group （83 cases） and control group （93 cases）. They were both given routine antihypertensive drugs for 6 months. The patients in the trial group were additionally given oral folic acid 5 mg once a day. The changes of plasma Hcy level and ambulatory blood pressure （ABP） were observed in the two groups before treatment and 6 months after treatment. Adverse drug reactions were also observed. RESULTS： Compared with before treatment and control group, the plasma Hcy level of patients in trial group was reduced significantly after 6 months treatment （P〈 0.05） ; compared with before treatment, the levels of blood pressure in 2 groups were decreased significantly after 6 months treatment （P〈0.05） ; there was no statistical significance between 2 groups （P〉0.05） ; the incidence of non-dipper hypertension in the trial group was lower than in control group （P〈0.05）. No significant adverse drug reaction was found in 2 groups. CONCLUSION： Folic acid can reduce the level of plasma Hcy and decrease the incidence of non-dipper hypertension in patients with type H hypertension.

关 键 词：叶酸 H型高血压 同型半胱氨酸 血压 非杓型血压 

分 类 号：R544.1[医药卫生—心血管疾病]