pH响应性P(AA-CO-C8PhEO10Mac)水凝胶的制备及其对L-抗坏血酸的控释性能  

Preparation of pH-Sensitive P(AA-co-C_8PhEO_(10)Mac) Hydrogel and Its Controlled-Release Properties on L-Ascorbic Acid

作　　者：王芳平[1] 牟琥珀[1] 张珺瑛[1] 李晚霞[1] 王其召[1] 杜新贞[1] 

机构地区：[1]西北师范大学化学化工学院,省部共建生态环境相关高分子材料教育部重点实验室,甘肃省高分子材料重点实验室,甘肃兰州730070

出　　处：《精细化工》2013年第2期134-138,共5页Fine Chemicals

基　　金：国家自然科学基金资助项目(21065010);甘肃省自然科学基金资助项目(1010RJZA013)~~

摘　　要：采用自由基交联共聚法合成了具有pH敏感性的水凝胶聚丙烯酸-co-甲基丙烯酸辛基酚聚氧乙烯醚酯〔P(AA-co-C8PhEO10Mac)〕,考察了不同单体配比的水凝胶在不同pH的缓冲溶液中的溶胀性、溶胀动力学和退溶胀动力学。通过浸泡法在水凝胶中载入L-抗坏血酸,初步研究了模拟胃肠液中,凝胶对L-抗坏血酸的释放行为。结果表明,凝胶兼具快速的溶胀和退溶胀速率,良好的pH敏感性等特征;载药凝胶在模拟肠液(SIF,pH=7.4)中对药物的累计释放率明显大于在模拟胃液(SGF,pH=1.4)中的累计释放率,增大丙烯酸的用量使累计释放率先升高后降低。采用滤纸片法研究了甲基丙烯酸辛基酚聚氧乙烯醚酯(C8PhEO10Mac)对大肠杆菌、酿酒酵母的抑制作用,结果显示,在10～50 mmol/L的测试浓度水平,C8PhEO10Mac对二者均无明显的抑制作用。A pH-sensitive PAA-co-octylphenyl polyoxyethylene methaerylate hydrogel [ P （AA-co- C8PhEO10Mac） ] was synthesized by free radical crosslinking polymerization. The swelling property, swelling and deswelling kinetics of the hydrogels in different pH media were studied. L-Ascorbic acid was chosen as a model drug and the controlled-release properties of the hydrogels were pilot-studied. The results show that the P（AA-co-C8PhEO10Mac） hydrogel has such characteristics as rapid swelling and deswelling rate and excellent pH sensitivity;the swelling ratios of the gels in simulated intestinal fluids （ SIF, pH = 7.4 ） were higher than those in simulated gastric fluids （ SGF, pH = 1.4 ）. With an increase of the content of acrylic acid, the swelling ratios of gels increased first and then decreased. The inhibitory effects of C8PhEOloMac on Escherichia coli and Saccharomyces cerevisiae were studied, and the results indicate that C8PhEO10Mac has no effect on them at the 10 -50 mmol/L test level.

关 键 词：水凝胶 PH敏感性 退溶胀动力学 体外释放 大肠杆菌 功能材料 

分 类 号：TQ320.61[化学工程—合成树脂塑料工业] TQ316.322