直接苷化法合成十二烷基糖苷放大实验工艺过程的优化  

Optimization of the Technical Process for the Amplification Experiments of Preparing Dodecyl Glycoside

作　　者：陈学梅[1] 

机构地区：[1]南京化工职业技术学院化学工程系,江苏南京210048

出　　处：《精细化工》2013年第2期139-143,共5页Fine Chemicals

摘　　要：在小试基础上,建立了一套反应釜体积为30 L直接苷化法合成十二烷基糖苷的实验室放大实验装置。考察了放大实验装置制备十二烷基葡萄糖苷的工艺参数的稳定性。结果表明,采用实验室小试工艺条件很难生产出与小试同等质量的烷基糖苷。指出了原料葡萄糖的含水量、醇糖摩尔比(简称醇糖比,下同)、葡萄糖在醇中的分散性及工艺参数的稳定性等因素影响了放大实验。最后确定优化的工艺条件为:原料葡萄糖选用无水的、且需过筛、脱水、预混合和分批投料;醇糖比为6∶1;温度、压力等工艺参数采用自动化控制;真空系统增设冷凝器和分离罐等。工艺过程优化后放大实验装置运行良好,所得产品经气相色谱仪分析与小试产品质量同等。A testing apparatus for the amplification experiments of preparing dodecyl glycoside in the 30 L reactor was set up in the lab. The effects of technological parameters on preparing stability were investigated. The acceptable product could not be obtained based on the experimental conditions of small scale plant. Water content in the glucose,raw material ratio, dispersity in the raw material, and the stability of the technological parameters were all the main influence factors of the amplification experiments. The experimental results indicate that the best technological parameters were as follows： glucose with no water must be sieved, premixed and batch fed ; raw material ratio was 6：1 ; parameters like temperature and pressure were automatically controlled by computer;condenser and knockout drum were added to the vacuum plant. The accuracy and reliability of the method have been verified.

关 键 词：烷基糖苷 直接苷化法 放大实验 优化 功能材料 

分 类 号：TQ423.2[化学工程]