涎液中口腔癌分子标志物的研究进展  

Research progress on molecular biomarkers of oral cancer in saliva

作　　者：胡逢春[1,2] 余东升[1,2] 黄洪章 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院口腔颌面外科 [2]广东省口腔医学重点实验室,广州510055

出　　处：《国际口腔医学杂志》2013年第2期265-267,272,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30973340);广东省自然科学基金重点资助项目(S2011020003247)

摘　　要：口腔癌是严重危害人类健康的疾病之一,患者在疾病的早期对其认识不足,往往使其得不到有效的控制;加之咀嚼和言语等活动的刺激,常使其在早期便发生转移,从而导致患者预后较差。研究显示,涎液中存在的一些分子物质与口腔癌的发生发展之间存在着一定的相关性,这就为其早期诊断和治疗以及改善患者预后提供了可能。本文就涎液成分的检测和口腔癌分子标志物的筛选等研究进展作一综述。Oral cancer is a one of the most important killer which threaten human＇s healthy severely. People usually have little acquaintance with it and treat it not seriously enough at the early stage; Additionally, the sti- mulations from the movement of the tongue and oral cavity when people are masticating and talking also can promote cancer cells metastasis. Consequently, the prognosis of oral cancer is usually pessimistic. In the recent years, some research validated that some molecules correlate with the tumorigenesis and progression of oral cancer, which provide probability for the early diagnosis and therapy for the oral cancer. Therefore, this review will discuss the detection of saliva and the selection of the biomarkers of the oral cancer.

关 键 词：涎液 分子标志物 口腔癌 诊断 

分 类 号：R739.81[医药卫生—肿瘤]