芪参复康胶囊对首发与复发抑郁症患者事件相关电位的影响  

A Comparative Study of ERPs between First-episode and Recurrent Depression Treated with Qishen Fukang Capsules

作　　者：杨来启[1] 陈玖[1] 魏敦宏[1] 高建宏[1] 杨喜民[1] 刘建新[1] 吴银霞[1] 吴兴曲[1] 

机构地区：[1]解放军第三医院全军精神病防治中心,陕西宝鸡721004

出　　处：《解放军药学学报》2012年第5期381-384,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：军队中医药科研专项课题;No.10ZYX108

摘　　要：目的探讨首发与复发抑郁症患者应用芪参复康胶囊治疗前后的临床症状、事件相关电位的变化差异。方法对解放军第三医院的40例首发抑郁症患者(首发组)、42例复发抑郁症患者(复发组)给予芪参复康胶囊治疗,分别于治疗前和治疗后8周评定24项HAMD及进行事件相关电位检查,与40名健康志愿者的结果进行比较。结果 (1)治疗后首发、复发组的HAMD评分均较治疗前显著下降,首发组:(30.01±5.41)分、(10.45±3.18)分;复发组:(30.45±4.28)分、(13.66±3.40)分。(2)与本组治疗前相比,首发、复发组治疗后P2、N2、P3潜伏期均显著缩短、波幅均显著升高;与首发组相比,治疗前复发组P3潜伏期显著延迟、P2、P3波幅均显著降低;治疗后复发组P2、N2、P3潜伏期仍显著延迟、波幅仍显著低于首发组。(3)与对照组相比,治疗前首发组、复发组P2、N2、P3潜伏期均显著延迟、波幅均显著降低;治疗后首发组P2、N2、P3潜伏期差异不显著,P3波幅仍显著偏低,P2、N2波幅无显著性差异,复发组P2、N2、P3潜伏期仍显著延迟、波幅仍显著低于对照组。结论首发、复发抑郁症患者接受芪参复康胶囊治疗后临床症状明显缓解、认知功能明显改善,疗效肯定。其中首发抑郁症患者疗效优于复发抑郁症。Objective To explore the features of clinical symptoms and event-related potential change before and after treatment between first-episode and recurrent depression treated with Qishen Fukang capsules. Methods 40 patients of first-episode depression and 42 cases of recurrent depression from the Third Hospital of PLA were given Qishen Fukang capsules for 8 weeks and their conditions were evaluated using 24-item Hamilton Depression Scale （HAMD）. The cognition function was determined by the change of P300 before and after treatment. Another 40 healthy controls were given the same test simultaneously. Results （ 1 ） The HAMD scores of patients decreased significantly first-episode （30.01 ± 5.41 ） score vs. （ 10.45 ± 3.18 ） score ; recurrent （ 30.45 ± 4.28 ） score vs. （ 13.66 ± 3.40） score. （2） After treatment, the latency period of P2, N2, P3 was shortened and amplitudes were elevated. Compared with first-episode group, the latency period of P3 was longer and the amplitude of P2, P3 was lower in recurrent depression group before treatment. The latency period of P2, N2, P3 was longer and the amplitude was lower in recurrent depressions group after treatment. （ 3 ） Compared with the controls, patients of first-episode and recurrent depression had longer latency periods and lower amplitudes of P2, N2, P3 before treatment. The latency period of P2, N2, P3 was of no statistical significance in first-episode patients after treatment. Conclusion The cognitive function has improved in patients with first-episode and recurrent depression after medication. Better effect is achieved among patients of first-episode depression.

关 键 词：芪参复康胶囊 首发 复发 抑郁症 事件相关电位 

分 类 号：R969.4[医药卫生—药理学]