超微粉碎技术的残黄片溶出度研究  

Dissolution Study of Canhuang Tablets Based on Ultrafine Powder Technology

作　　者：李仙义[1] 靳世英[2,3] 靳士晓[2,3] 吕俊兰[2,3] 陈红鸽[2] 韩晋[2] 袁海龙[2] 

机构地区：[1]总后勤部卫生部药品仪器检验所,北京100166 [2]解放军302医院,北京100039 [3]成都中医药大学,四川成都611730

出　　处：《解放军药学学报》2012年第6期506-508,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：军队十二五中医药重点课题;No.20100124

摘　　要：目的研究超微粉碎技术对残黄片溶出度的影响。方法采用超微粉碎技术对原料药材进行粉碎,压片,以盐酸溶液(pH 1.0)为溶出介质,采用桨法测定体外溶出度,比较基于超微粉碎技术的残黄片和普通粉碎的残黄片的溶出速率和溶出量。结果基于超微粉碎技术的残黄片的体外累积溶出率相比基于普通粉碎的残黄片有显著提高。结论超微粉碎技术工艺简单易行,可提高残黄片有效成分的溶出。Objective To study the effect of ultrafine powder technology on the dissolution of Canhuang tablets. Methods Raw medicinal materials were crushed using ultrafine powder technology and subsequently pressed into tablets. With hydrochloric acid solution （ pH 1.0） as the dissolvent, the dissolution rate and amount of berberine hydro chloride from the Canhuang tablets based on ultrafine powder as well as ordinary powder were determined and compared using the paddle method. Results The accumulated dissolution of Canhuang tablets in vitro based on ultrafine powder is significantly higher than that of ordinary powder tablets. Conclusion Ultrafine powder technology is feasible and can improve the dissolution rate markedly in vitro.

关 键 词：残黄片 超微粉碎技术 溶出度 

分 类 号：R927.2[医药卫生—药学]