延边地区朝鲜族胰岛素受体底物1基因Gly972Arg多态性与2型糖尿病的相关性  

Correlation study between the Gly972Arg polymorphism of insulin receptor substrate 1 and type 2 diabetes mellitus in Korean-Chinese of Yanbian

作　　者：李卿姬[1] 吴英花[1] 宫克宇[1] 周文敬[1] 

机构地区：[1]延边大学附属医院,吉林延吉133000

出　　处：《延边大学医学学报》2012年第4期235-238,共4页Journal of Medical Science Yanbian University

摘　　要：[目的]研究延边地区朝鲜族人群胰岛素受体底物l(IRS-1)基因Gly972Arg多态性与2型糖尿病的关系.[方法]应用聚合酶链反应-单链构象多态性分析延边地区298人的IRS-1基因Gly972Arg突变位点基因型,其中2型糖尿病组为89人(朝鲜族42人,汉族47人),正常对照组为209人(朝鲜族120人,汉族89人).[结果]正常对照组中汉族的IRS-1基因Gly972Arg多态性的突变率(即G/A基因型频率)高于朝鲜族(3.37%,2.50%),但差异无统计学意义(χ2=1.39,P=0.709);2型糖尿病组中朝鲜族的G/A基因型频率略高于汉族(4.76%,2.13%),但差异亦无统计学意义(χ2=1.107,P=0.744).[结论]IRS-1基因Gly972Arg多态性可能不是延边地区朝鲜族人群2型糖尿病的重要遗传因素.OBJECTIVE To study the correlativity between the insulin receptor substrate 1 （IRS-1） gene Gly972Arg polymorphism and type 2 diabetes mellitus（T2DM） in Korean-Chinese of Yanbian. METHODS Using the PCR-SSCP, mutational site genotypes in the Gly972Arg of IRS-1 gene were analyzed in 298 cases of subjects in Yanbian area, including 89 cases of subjects（Korean-Chinese n= 42, Han nationality n = 47） in T2DM group and 209 cases of subjects（Korean-Chinese n = 120, Han nationality n = 89） in normal control group. RESULTS The mutation rate （G/A genotype） in Gly972Arg of IRS-1 gene were higher in Han nationality than in Korean-Chinese （3.37% and 2.50%） with no statistically significant difference （;（2 = 1.39, P = 0. 709）, and the allele frequency of Gly972Arg of IRS-1 gene polymorphism in T2DM group were little higher in Korean-Chinese than in Han nationality （4.76% and 2.13% ） with no statistically significant difference （x2 = 1. 107, P = 0. 744）. CONCLUSION Gly972Arg mutation of IRS-1 gene may not be an important hereditary factor for T2DM in the Korean-Chinese of Yanbian area.

关 键 词：胰岛素受体底物1 糖尿病 非胰岛素依赖型 朝鲜族 

分 类 号：R392.1[医药卫生—免疫学]