乙酸乙酯类衍生物对小鼠学习记忆再现障碍的影响  

Improving effect of acetic ether derivatives to reconstruction dysfunction of learning and memory in mice

作　　者：李迎军[1] 崔艾丽[2] 张红英[1] 

机构地区：[1]延边大学医学院机能学实验中心 [2]延边大学附属医院皮肤科,吉林延吉133002

出　　处：《延边大学医学学报》2012年第4期252-254,共3页Journal of Medical Science Yanbian University

摘　　要：[目的]研究2-[1-(4-甲基哌嗪)]-2-[1-(2-吡啶)乙氧基]乙酯(促忆5号)和1-[1-(4-甲基哌嗪)]-2-[1-(2-吡啶)乙氧基]乙酮(促忆6号)对乙醇所致小鼠记忆再现障碍的影响.[方法]将小鼠随机分为正常对照组、模型对照组、脑复康(3g/kg)阳性组、促忆5号大、小剂量(40,20mg/kg)组,促忆6号大、小剂量(40,20mg/kg)组,连续灌胃给予7d.采用乙醇建立记忆再现障碍模型,以避暗法和水迷宫法观察促忆5号和6号对小鼠学习记忆的影响.[结果]促忆5号和6号均可使避暗法小鼠潜伏期延长,错误次数明显减少,使水迷宫法小鼠到达时间缩短,错误次数减少,促忆5号及6号略优于脑复康.[结论]促忆5号和6号均对小鼠学习记忆有一定的改善作用.OBJECTIVE To study the improving effect of 2-[-1-（4-Methylpiperazine）]-2-[1-（2-Pyridine） Ethoxy] （Promoting Memory No. 5） ethyl and 1-（4-Methylpiperazin-l-yl）-2-（ 1-（pyridin-2-yl） Ethoxy） Ethanone（Promoting Memory No. 6）to reconstruction dysfunction of learning and memory in mice. METHODS The mice were divided into 5 groups： control group, model group, capsule of brain compound group, large and small dosage of P M No. 5 （40, 20 mg/kg） groups and P M No. 6 （40, 20 mg/kg） groups. They were ig drug ethyl 7 days continuously, and to establish the model of memory reconstruction dysfunction in mice of P M No. 5 and P M No. 6 to effect of learning and memory with the darkness avoidance test and the water maze test. RESULTS P M No. 5 and P M No. 6 were reduced error frequency and prolonged latency with the darkness avoidance test, it is shortened arrival time and reduce error frequency with the water maze test. CONCLUSION P M No. 5 and P M No. 6 have improving effect to learning and memory in mice.

关 键 词：学习记忆 再现障碍 乙酸乙酯类衍生物 小鼠 

分 类 号：R338.64[医药卫生—人体生理学]