超脉冲CO_2激光辅助耳蜗底周开窗术对大鼠听力的影响  

Effects on hearing of rat following cochleostomy in basal turn assisted by superpulsed CO_2 laser

作　　者：耿阳[1] 叶青[1] 田天捷[1] 张先增[2] 詹振林[2] 谢树森[2] 

机构地区：[1]福建医科大学省立临床医学院耳鼻咽喉科,福州350001 [2]福建师范大学激光与光电子技术研究所福建省光子技术重点实验室医学光电科学与技术教育部重点实验室,福州350007

出　　处：《福建医药杂志》2012年第4期1-2,67,共3页Fujian Medical Journal

基　　金：国家自然科学基金资助项目(60878062);卫生部科学研究基金福建省卫生教育联合攻关计划项目(WKJ2008-02-035);福建省自然科学基金项目(2011J01135)

摘　　要：目的探讨超脉冲模式的CO2激光辅助耳蜗底周开窗对SD大鼠听力产生的影响。方法将24只SD大鼠随机分为激光辐照组(2W组和5W组)、假手术组及正常对照组,分别用相应功率的超脉冲CO2激光对大鼠右耳行耳蜗底周开窗术,于术前及术后2天测听其听性脑干反应(ABR)。结果激光辅助耳蜗底周开窗后,2W组和5W组的ABR阈值均有升高,听力损失幅度随测定频率的升高呈递增趋势;5 W组的开窗口周围炭化斑明显,窗口明显较2 W组的大。结论超脉冲CO2激光辅助耳蜗底周开窗时对听力具有一定的风险,激光手术前应充分权衡利弊。Objective To investigate the effects on hearing following CO2 laser-assisted cochleostomy at the basal turn in SD rat in superpulsed mode.Methods Twenty-four SD rats were randomly devided into laser 2 W group,laser 5 W group,sham-operated group,and normal control group.A laser-assisted cochleostomy was performed using superpulsed CO2 laser with a power energy of 2 W or 5 W.Auditory brainstem responses（ABR） thresholds were measured preoperatively and postoperatively.Results ABR thresholds shifted in both laser-irradiated groups.The values of the tone burst-ABR threshold shifts in both laser groups were greater with increasing frequency;More carbonization,as well as larger openings,were noted in 5 W group than in 2 W group.Conclusion There is a risk of hearing injury,and thus caution should be taken when performing a cochleostomy at basal turn assisted by superpulsed CO2 laser.

关 键 词：耳蜗 听性脑干反应 CO2激光 超脉冲 

分 类 号：R764.35[医药卫生—耳鼻咽喉科] R-332[医药卫生—临床医学]