烧伤患者血清TPO变化及其临床意义  

The relation between clinic and changes of serum TPO in burn patients

作　　者：郑德义[1] 赵桂香[1] 程代薇[1] 付晋凤[2] 李自力[1] 郑庆桂[1] 

机构地区：[1]贵州省人民医院烧伤整形科,贵阳550002 [2]云南省昆明医学院第二附属医院烧伤科

出　　处：《贵州医药》2012年第6期486-488,共3页Guizhou Medical Journal

摘　　要：目的探讨烧伤患者早期血清TPO水平动态变化及其临床意义。方法26例烧伤患者,烧伤面积20%～96%TBSA,分别于烧伤后1,3,7,10d抽取静脉血常规,采用ELISA方法测定血清TPO值。结果 (1)中度烧伤血清TPO呈逐渐升高趋势,但各时相与正常对照组之间相比较,差异无显着性(P>0.05);重度及以上烧伤患者血清TPO升高,与正常对照组比较,烧伤7d以后血清TPO明显升高(P<0.01)。(2)与正常对照组比较,血小板数量伤后3d明显降低(P<0.01),10d明显升高,差异有显着性(P<0.01),并表现血小板增多;(3)TPO与血小板数之间呈正相关(r=0.196,P<0.05)。结论烧伤严重程度影响烧伤患者血清TPO变化,感染期TPO升高可能是烧伤患者血小板增多的重要因素。Objective To investigate the role and dynamic change of thrombopoietin （TPO） of the early serum pathogenesis in the burned patients. Methods26 burned patients with 49.84±24.84% TB- SA （range, 20-96%） were studied. Blood samples were collected in the morning of ld, 3d, 7d and 10d post-burn. The blood routine was measured by automatic machine, and serum TPO concentrations were detected by ELISA method according to reagent instruction. In addition, blood samples of 13 health adults were served as control group. Resultswhen compared with control group, the serum TPO of burned patients （〈50%TBSA） increased gradually （P〉0.05）, but in the burned patients （〉50% TBSA） the TPO concentration significantly increased from 7d post-burn （P〈0.01）. Compared to the control group, the platelet amount of 3d after burn decreased sharply （P〈0.01）, but increased signif-icantly since 10d post-burn （P〈0.01） when thrombocytosis was found. According to person correla-tion analysis, the serum TPO level had a positive relative to the platelet amounts （r=0. 196, P〈0.05）. Conclusion The burn severity but not the platelet count induces the change of serum TPO level, and the elevated TPO may contribute to thrombocytosis in burn patients.

关 键 词：烧伤 血小板 血小板生成素 

分 类 号：R644[医药卫生—外科学]