中蒙两国治疗AECOPD药物分析  

Drug utilization review of AECOPD patients in China and Mongolia

作　　者：吉布胡兰[1] 蒙龙[1] 丁选胜[1] 方芸[2] 

机构地区：[1]中国药科大学临床药学教研室,江苏南京210009 [2]南京大学医学院附属鼓楼医院,江苏南京210008

出　　处：《安徽医药》2012年第8期1179-1181,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析比较中国、蒙古国两国慢性阻塞性肺疾病急性加重期(AECOPD)患者的用药情况,为临床合理用药提供依据。方法收集2009—2010年南京大学医学院附属鼓楼医院(中国)和国家中央医院(蒙古国)呼吸科的AECOPD病历,对患者情况和治疗药物的使用情况进行统计分析,并依照慢性阻塞性肺疾病全球创议评价两院治疗AECOPD所用药品的合理性和安全性。结果鼓楼医院和国家中央医院两年内共有1052人次(695 vs 357)入院,其中接受支气管扩张剂,磷酸二酯酶抑制剂,糖皮质激素和抗菌药治疗的比率分别为87.1%vs 80.1%,82.9%vs 78.43%,54.7%vs 73.1%,98.5%vs 82.07%。在抗感染治疗方面,鼓楼医院使用的抗菌药等级较高,疗程更长,但抗感染失败率和住院天数更长。结论两院药品的使用基本合理,但是仍存在磷酸二酯酶抑制剂和抗菌药使用过多,糖皮质激素使用偏少等问题。Objective To compare the drugs for treatment of AECOPD patients in China and Mongolia,so as to provide a basis for clinical rational drug use.Methods We retrospectively analyzed medical records of acute exacerbation of Chronic Obstructive Pulmonary Disease（AECOPD）hospitalized patients in Drum Tower Hospital,China and State Central Hospital,Mongolia,from January 2009 to December 2010.Treatment was evaluated according to Global Initiative for Chronic Obstructive Lung Disease（GOLD）.Results The study involved 1052 patient records,including 695 records identified in Drum Tower Hospital and 357 in State Central Hospital.Clinicians prescribed bronchodilators in 87.1% cases,methylxanthines in 82.9% cases,steroids in 54.7% cases,and antibiotics in 98.5% cases in Drum Tower Hospital.But,a total prescription in State Central Hospital was bronchodilators in 80.1% cases,methylxanthines in 78.4% cases,steroids in 73.1% cases,and antibiotics in 82.1% cases.Conclusion Although clinical treatment of AECOPD was basically in accordance with GOLD,utilization of antibiotics and methylxanthines was frequently higher than recommendation.Bronchodilator and system steroids therapy was lower than international recommendation in both hospitals.

关 键 词：中国 蒙古国 慢性阻塞性肺疾病急性加重期 药物分析 

分 类 号：R563.9[医药卫生—呼吸系统]