持续气道正压通气对阻塞性睡眠呼吸暂停综合征患者血清血管紧张素转换酶水平的影响  

Effect of continuous positive airway pressure treatment on serum angiotensin converting enzyme levels in patients with obesity-associated obstructive sleep apnea syndrome

作　　者：沈文富[1] 李红苗[1] 王强[1] 王骏[1] 蒋冬兰[1] 严锡祥 

机构地区：[1]建湖县人民医院呼吸科,江苏建湖224700

出　　处：《江苏大学学报（医学版）》2012年第5期430-433,共4页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:探讨持续气道正压通气(continuous positive air-way pressure,CPAP)对阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)患者血清中血管紧张素转换酶(angiotensin converting enzyme,ACE)水平的影响。方法:根据睡眠期多导睡眠监测中的呼吸暂停低通气指数(apnea hypopnea index,AHI)检查结果,选择43例符合OSAS诊断标准的患者作为研究对象(OSAS组),测定OSAS组实施CPAP治疗1个月前后ACE水平,与AHI正常者(正常组)比较,并分析OSAS组中ACE与睡眠呼吸紊乱指数的相关性。结果:OSAS组治疗前ACE浓度(23.35±15.62)U/L显著低于正常组(38.95±21.83)U/L(P<0.05),行CPAP治疗1个月后OSAS组ACE浓度为(24.55±14.89)U/L,与治疗前比较差异无统计学意义(P>0.05),相关性分析显示OSAS组中ACE浓度与AHI无明显相关性(r=-0.018,P>0.05)。结论:OSAS患者血清中ACE水平与睡眠呼吸紊乱指数无明显相关性,与正常人相比,OSAS患者血清ACE显著降低,CPAP治疗不能影响ACE水平变化。Objective： To investigate the influence of continuous positive airway pressure （CPAP） treat- ment on the serum angiotensin converting enzyme levels in patients with obstructive sleep apnea syndrome （OSAS）. Methods： Based on apnea hypopnea index （AHI） measured by polysomnography, 43 patients were diagnosed as OSAS （OSAS group） and enrolled in this study. The serum ACE levels of OSAS group were measured and compared with the subjects without OSAS（ normal groups）. In patients with OSAS, the relationship between levels of ACE and AHI were analyzed. Results： Compared with normal group [ （38.95 ± 21.83 ） U/L], serum ACE levels in OSAS group [ （23.35 ± 15.62） U/L,P 〈 0.05 ] were significantly reduced before CPAP treatment. In OSAS group, serum ACE level after CPAP treatment[ （24.55 ± 14.89） U/L] was similar to those before CPAP treatment（ P 〉 0.05 ）. No relationship was observed in OSAS group between the ACE levels and AHI levels. Conclusion： The serum ACE levels in OSAS group was signifi- cantly higher than in normal group. The CPAP treatment cannot change the ACE level in OSAS patients. The serum ACE levels were not correlated with the AHI levels in OSAS patients.

关 键 词：睡眠呼吸暂停综合征 呼吸暂停低通气指数 持续气道正压通气 血管紧张素转换酶 

分 类 号：R563[医药卫生—呼吸系统]