不同糖调节受损状态对早期动脉粥样硬化的影响  

Association between different impaired glucose regulation and the early-stage arteriosclerosis

作　　者：赵静[1,2] 梁军[2] 窦连军[2] 龚莹[2] 腾飞[2] 

机构地区：[1]徐州医学院研究生学院,江苏徐州221009 [2]徐州市中心医院内分泌科,江苏徐州221009

出　　处：《江苏大学学报（医学版）》2012年第5期440-443,共4页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:探讨糖尿病前期不同血糖水平对颈-股动脉脉搏波传导速度(carotid-to-femoral pulse wave velocity,c-fPWV)的影响。方法:对5 098例非糖尿病者的空腹血糖、口服葡萄糖耐量试验2小时血糖(2-hour oral glucose toler-ance test,2h OGTT)、糖化血红蛋白(hemoglobin A1c,HbA1c)和c-f PWV水平进行分析。结果:空腹血糖受损(im-paired fasting glucose,IFG)组、糖耐量受损(impaired glucose tolerance,IGT)组和高HbA1c组与糖耐量正常组的c-fPWV差异分别为0.97 m/s、1.08 m/s和0.92 m/s,差异有统计学意义(P<0.01)。高HbA1c合并IFG、高HbA1c合并IGT的c-f PWV明显高于单纯高HbA1c(P=0.036,P=0.03)。IFG合并高HbA1c、IGT合并高HbA1c的c-f PWV明显高于单纯IFG和单纯IGT(P=0.02,P=0.04)。结论:c-f PWV水平与糖尿病前期相关联,并独立于其他代谢因素。IFG合并高HbA1c、IGT合并高HbA1c对c-f PWV水平的影响呈叠加效应,提示糖尿病前期不同糖调节受损状态均可引起血管弹性的改变,导致早期动脉粥样硬化发生。Objective： To explore the associations of glucose exposure and carotid-to-femoral pulse wave velocity （ c-f PWV） in prediabetes adults. Methods： Fasting plasma glucose, 2-hour oral glucose tolerance test （2h OGTT）, hemoglobin Alc（HbAlc） and c-f PWV were analysed in 5 098 non-diabetes subjects. Results： We found that the differences in c-f PWV between individuals with impaired fasting glucose （IFG）, impaired glucose tolerance （IGT）, high HbAlc and those without these abnormalities were 0.97 m/s, 1.08 rn/s and 0. 92 m/s （ P 〈 0. 01 ）. In addition, our data indicated that individuals of both high HbA1 e and IFG or IGT had significantly higher levels of c-f PWV compared with those who only had high HbAlc （P =0. 036 and 0.03, respectively） ; or those only had IFG （P =0.02） ; or only had IGT （P = 0.04）. Conclusion： c-f PWV was associated with prediabetes, independent of metabolic risk factors. We found that individuals of both high HbAlc and IFG or IGT had additive effects on c-f PWV, and all these alterations may contribute to development and progression of atherosclerosis.

关 键 词：糖尿病前期 脉搏波传导速度 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病] R587.1[医药卫生—内科学]