碱性成纤维细胞生长因子在AECOPD患者治疗前后血清中的变化及意义  

The changes and significance of bFGF in serum of the patients with chronic obstructive pulmonary disease during acute exacerbation stage before and after treatment

作　　者：朱益鹏[1] 周影娜[2] 

机构地区：[1]河北省鄂州市中心医院呼吸内科,研究生436000 [2]贵阳医学院附院呼吸科,550004

出　　处：《贵州医药》2012年第4期301-304,共4页Guizhou Medical Journal

摘　　要：目的通过检测慢性阻塞性肺疾病(COPD)急性加重期患者治疗前后血清中碱性成纤维细胞生长因子(bFGF)水平,对bFGF在COPD中的变化及其与肺功能的相关性进行研究。方法选择COPD急性加重期患者45例(COPD组),并按肺功能分级分为Ⅰ级(轻度组)、Ⅱ级(中度组)、Ⅲ级(重度组),每组各15例,健康自愿者15例(对照组),采用双抗夹心ELISA法,对各组COPD患者入院时及治疗缓解后的血清bFGF含量进行测定,并同步行肺功能及相关检查,将各患者组所测结果与对照组对比分析。结果 (1)COPD各组治疗前后血清bFGF均高于对照组,且治疗后bFGF水平较治疗前下降(P<0.05);COPD各组治疗前后bFGF水平随分级增加而增高,其中中度组、重度组治疗前后bFGF与轻度组之间差异有统计学意义(P<0.05)。(2)COPD组治疗前后FEV1%Pred、FEV1/FVC%、MMEF%Pred、V50%Pred、V25%Pred明显低于对照组,经治疗后,COPD组各项肺功能指标均升高(P<0.05)。(3)COPD急性加重期患者治疗前后血清bFGF与肺功能指标FEV1%Pred、FEV1/FVC%、V50%Pred、V25%Pred、MMEF%Pred呈负相关。结论COPD组患者在病情急性加重期和治疗缓解后血清bFGF水平均升高,并与疾病严重程度及气流受限程度有关,提示bFGF在COPD炎症及气道重塑中可能具有一定作用。Objective To investigate the changes of basic fibroblast growth factor （bFGF） in ser- um of patients with chronic obstructive pulmonary disease （COPD） during acute exacerbation stage be- fore and after treatment and its relationship with lung function. Methods 45 inpatients with acute exac- erbation of COPD （COPD group） and 15 healthy volunteers （control group） were included in this study. COPD patients were divided into groups according to lung function which were grade I （mild group）, grade Ⅱ （moderate group）, grade Ⅲ（severe group） and each group was 15 cases. The serum samples were collected from COPD patients before and after therapy. The concentrations of bFGF in serum were measured by enzyme-linked immunosorbent assay （ELISA）. Meanwhile the lung function and related inspection items were also measured. The results of patients were compared with those of healthy volunteers. Results The serum concentrations of bFGF in COPD various groups before and after treatment were significantly higher than those in control group, and after treatment, the levels of bF- GF were decreased compared with before （P〈0.05）. The serum levels of bFGF in COPD various groups before and after treatment had a raised tendency with the increase of grade, the differences be- tween moderate group and mild group/severe group and mild group were obvious （P〈0. 05）. The levels of FEV% Pred, FEV1/FVC%, MMEF% Pred, V50%Pred, V25%Pred in COPD groUp be- fore and after treatment were obviously lower than those in control group （P〈0.05）, after treatment, the indicators were all improved compared with before （P,（0.05）. The levels of bFGF in patientswith COPD during acute exacerbation negatively correlated with those of FEVI%Pred, FEV%FVC%, MMEF%Pred, V50%Pred, and V25 %Pred. Conclusion The levels of bFGF in patients with COPD both during acute exacerbation and after treatment are significantly increased, which are associ- ated with the severity of disease and airflow limitation, bFGF may pl

关 键 词：慢性阻塞性肺疾病 碱性成纤维细胞生长因子 

分 类 号：R563.9[医药卫生—呼吸系统]