化痰解郁通淋汤为主治疗慢性尿酸性肾病疗效观察  

Study on the therapy effect and safety of Phlegm-dissipating and Stagnation-resolving and Strangury-freeing Decoction in the uric acid nephropathy.

作　　者：刘加林[1] 孔庆歆[2] 何琳[2] 吴静[3] 黄霞[1] 沈燕[1] 颜平[2] 

机构地区：[1]贵州省人民医院肾内科,贵阳550002 [2]贵州省中西医结合医院(贵州省疾病控制中心附属医院),550008 [3]遵义医学院

出　　处：《贵州医药》2012年第4期308-311,共4页Guizhou Medical Journal

基　　金：贵州省中医管理局中医药科学技术研究专项基金资助项目(2009079)

摘　　要：目的观察化痰解郁通淋汤为主中西医结合治疗尿酸性肾病的临床疗效和安全性。方法80例慢性尿酸性肾病患者随机分为中西医结合组(治疗组)和对照组各40例,两组均予以低嘌呤饮食、多饮水、禁酒并以别嘌醇100mg,1日1-2次,碳酸氢钠等对症治疗,治疗组在此基础加用中药化痰解郁通淋汤口服1日1剂,每周5剂,休息2日;两组均以4周为1疗程,共观察3个疗程。结果 (1)治疗组总有效率为87.5%(35/40),对照组为57.5%(23/40),治疗组疗效优于对照组(P<0.05)。(2)两组治疗前后中医症状体征积分比较有统计学意义(P<0.05)(3)治疗后治疗组血尿酸(SUA)、血肌酐(SCr)、血尿素氮(BUN)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、血β2微球蛋白(β2-M)、尿β2微球蛋白(β2-M)、24小时尿蛋白定量均明显改善,且优于对照组(P<0.05),(P<0.01)。(4)治疗后两组SUA均显著降低(P<0.01),且治疗组优于对照组(P<0.01);治疗组SCr、BUN亦明显改善(P<0.05)。结论化痰解郁通淋汤结合常规西药治疗慢性尿酸性肾病有较好的疗效和安全性。Objective To observe the clinical efficacy and safety of the Comprehensive Therapy with the Phlegm-dissipating and Stagnation-resolving and Strangury-freeing Decoction in the treatment of uric acid nephropathy. Methods The 80 cases of chronic uric acid nephropathy were randomly divid- ed into integrative medicine group （treatment group） and the control group which were 40 patients for each group. Both of two groups were to be low-purine diet, drinking more water, prohibition and treated by sodium bicarbonate and allopurinol 100mg, 1 - 2 times a day. On the basis of symptomatic treatment, the Phlegm-dissipating and Stagnation-resolving and Strangury-freeing Decoction were ap- plied in the treatment group, who were given traditional Chinese medicine orally one medicament each day, 5 times a week, rested 2 days. All patients were in four weeks course of treatment, observation of a total of three courses. Results The total effective rate of treatment group was 87. 5%, control group was 57.5~. There were statistics significant difference sbetween the two group （P＇~0. 05）. After treatment, the different between the two group were significantly about the integral of TCMsymptoms and signs. In the treatment group, SUA, hour urinary protein were significantly decreased after SCr, BUN,TG, TC, HDL,t32-M, u/32-M, 24- treatment, and there were statistics significant differences between the two group （P〈0.05,P^0.01）. After treatment, the SUA were significantly lower （P〈0.01）, and the treatment group was better than the control group （P〈0.01）. The treat- ment group of SCr, BUN, also improved significantly （P〈0.05）. Conclusion The Phlegm-dissipating and Stagnation-resolving and Strangury-freeing Decoction plus conventional western medicine treat- ment has effective and safety for chronic uric acid nephropathy

关 键 词：慢性尿酸性肾病 中西医结合疗法 化痰解郁通淋汤 别嘌醇 

分 类 号：R692[医药卫生—泌尿科学] R277.5[医药卫生—外科学]