四株野生灵芝水提物抑制不同肿瘤细胞生长的效果比较  

In vitro Inhibition of Tumor Cells by Aqueous Extracts of Five Ganoderma Strains

作　　者：张智[1] 胡惠萍[1] 焦春伟[1] 钟华梅[1] 杨小兵[1] 

机构地区：[1]广东省微生物研究所,广东省菌种保藏与应用重点实验室,广东省微生物应用新技术公共实验室,广东粤微食用菌技术有限公司

出　　处：《食用菌学报》2012年第4期83-86,共4页Acta Edulis Fungi

基　　金：高新技术产业化项目(编号:2010A010500007);广东省工程技术研究开发中心项目(编号:00646562290531052);广东省中国科学院全面战略合作项目(编号:2010B090301035)的部分研究内容

摘　　要：对1株野生赤芝(Ganoderma lucidum)和3株野生无柄紫灵芝(G.mastoporum)经驯化栽培的子实体以及对照栽培菌株赤芝HZ8的子实体分别制备水提物,进行人恶性乳腺癌细胞株MT-1(human breastcancer)和人肝癌细胞HepG2(human hepatoma)两种肿瘤细胞体外抑制试验。结果显示:3株无柄紫灵芝对肿瘤细胞MT-1和HepG2的生长抑制效果优于赤芝,5株灵芝对MT-1细胞的抑制率均高于对HepG2细胞的抑制率,提示MT-1细胞比HepG2细胞对样品功效的敏感程度较高。The inhibitory effects of aqueous extracts of five Ganoderma strains on the proliferation in vitro of MT-1 （human breast cancer） and HepG2 （human hepatoma） cell lines were evaluated. Fruit bodies of four strains （G. lucidum N12, G. mastoporum strains N132, Nl19 and N85） were collected from the wild, and G. lucidurn （strain HZ8） was a cultivated strain included as a control. Our data showed that inhibition by aqueous extracts of the three G. mastoporum strains was stronger compared with the wild G. lucidum strain. Furthermore, aqueous extracts of all five test strains were more inhibitory to MT-1 cells compared to HepG2 cells.

关 键 词：灵芝 野生菌株 肿瘤细胞 抑制 

分 类 号：R285[医药卫生—中药学]