何首乌致药物性肝损伤患者临床分析  

Clinical analysis of patients with drug-induced liver injure by Polygonum Multiflorum Thumb

作　　者：陈仕祥[1] 范平[1] 何维新[1] 江军[1] 熊志远[1] 

机构地区：[1]解放军第一一三医院感染科,宁波315040

出　　处：《中华消化病与影像杂志（电子版）》2012年第4期14-16,共3页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的总结何首乌致药物性肝损伤患者临床特征。方法2006年5月至2010年3月解放军第一一三医院收治的何首乌致药物性肝损伤患者12例。详细记录每例患者服药史、临床表现、肝功能、凝血酶原时问、肝炎标志物检查情况、自身免疫相关检查情况、影像学检查情况、治疗经过及预后。结果何首乌致药物性肝损伤潜伏期为15～90d，主要临床表现为乏力、纳差、皮肤巩膜黄染，4例伴皮肤瘙痒，3例肝大，2例腹腔积液；肝功能测值均明显升高，以丙氨酸转氨酶升高为主，66．7％（8／12）患者伴黄疸，以直接胆红素升高为主；重症药物性肝损伤2例。结论何首乌可引起肝功能损伤，肝功能损伤者多数伴有黄疸，预后较好。Objective To analyze the clinical characteristics of 12 patients with drug-induecd liver injure（DILI） by Polygonum Maltiflorum Thumb （PMT）. Methods A total of 12 patients with DILI by PMT was admitted to the l l3th hospital of People＇s Liberation Army between May 2006 to March. 2010 in this study. The collecting information for every patient included the history of medicine, clinical manifestation, liver function, prothrombin time, hepatitis markers, autoimmune related antibody, imaging examination, treatment and prognosis. Results Latent period for PMT-induced liver injury was 15-90 days and the major clinical pictures were characterized by fatigue, anorexia and jaundice of skin and sclera, with pruritus in 4 cases, hepatomegaly in 3 cases and ascites in 2 cases. There is marked elevation in aminotransferase, especially for alanine transaminase. Jaundice occurred in 66. 7% of the patients, dominated by direct bilirubin and severe DILI was observed in 2 cases. Conclusion PMT can induce liver injure accompanying with jaundice ,and its prognosis is good.

关 键 词：药物性肝损伤 体征和症状 预后 何首乌 

分 类 号：R595.3[医药卫生—内科学]