抗磷脂抗体相关性复发性流产的诊治  

作　　者：林其德[1] 苏小玲[1] 

机构地区：[1]上海交通大学医学院附属仁济医院妇产科,上海200001

出　　处：《中国实用妇科与产科杂志》2013年第2期106-108,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：大量研究表明抗磷脂抗体可导致复发性流产,原因不明复发性流产伴抗磷脂抗体阳性属于抗磷脂综合征范畴。发病机理研究表明抗磷脂抗体可以通过高凝状态、血栓形成和直接损伤滋养细胞导致流产。抗磷脂抗体阳性的复发性流产患者的治疗应该是短疗程、个体化。阿司匹林、肾上腺皮质激素和低分子肝素的剂量和疗程主要根据患者外周血抗磷脂抗体水平、血小板聚集情况、D-D聚体水平变化进行调整。但其诊治尚待进一步的探讨。Numerous studies show that antiphospho-lipid antibodies can cause recurrent miscarriage, un-explained recurrent miscarriage associated with an-tiphospholipid antibodies are antiphospholipid anti-body syndrome scope. The studies showed that path-ogenesis of antiphospholipid antibodies including pla-cental hypercoagulable state, thrombosis and direct damage of trophoblast cell, could lead to miscarriage. Treatment for antiphospholipid antibody-positive pa-tients with recurrent miscarriage could be short course and individualized. The dose and duration of aspirin, adrenal corticosteroids and low molecular weight heparin therapy should be adjusted , according to antiphospholipid antibodies, platelet aggregation and the D-D dimer level in the peripheral blood of patients. However, the diagnosis and treatment has yet to be further explored.

关 键 词：抗磷脂抗体 抗磷脂综合征 抗心磷脂抗体 抗β2-GP1抗体 复发性流产 

分 类 号：R714.21[医药卫生—妇产科学]