正交试验法优选甘草制吴茱萸的炮制工艺  

Optimization of Processing Technology for Radix Glycyrrhizae Processing Fructus Evodiae with Orthogonal Test

作　　者：郭昊[1] 曹岗[1] 丛晓东[1] 蔡皓[2,3] 蔡宝昌[1,2,3] 

机构地区：[1]浙江中医药大学中药炮制技术中心,浙江杭州311401 [2]南京中医药大学,江苏南京210046 [3]南京中医药大学,江苏省中药炮制重点实验室,江苏南京210049

出　　处：《中华中医药学刊》2013年第2期326-328,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏高校优势学科建设工程资助项目;南京中医药大学中药学一级学科开放课题资助项目(2011ZYX2-006);浙江省卫生厅省共建资助项目(WKJ2010-2-019);浙江中医药大学校级科研基金资助项目(17211093)

摘　　要：目的:优选甘草制吴茱萸的炮制工艺,为规范制吴茱萸的炮制工艺提供依据。方法:采用L9(34)正交试验设计,以吴茱萸碱、吴茱萸次碱两种生物碱的总含量为评价指标,考察甘草用量、烘干温度、烘干时间3因素对指标成分的影响,最终确定甘草制吴茱萸的最佳炮制工艺。结果:甘草汁用量对吴茱萸中生物碱的含量有显著影响,甘草汁用量6.5%,烘干温度60℃,烘干时间8 h。结论:本研究为规范甘草制吴茱萸的炮制工艺提供了部分科学依据。Objective： To optimize the preparative technology of Radix Glycyrrhizae processing Fructus Evodiae and provide the basis to standard scientific reference of Radix Glycyrrhizae processing Fruetus Evodiae. Method： The total yields of evodiamine and rutaecarpine were chosen as the evaluating indicators. L9 （ 34 ） orthogonal test design was applied to investigate the influence of dosge of Radix Glycyrrhizae, drying temperature and drying time, ultimately determine the best preparative technology. Result ： The dosge of Radix Glycyrrhizae is vital to the content of alkaloids. The study showed that the best preparative technology was as follows：the dosage of Radix Glycyrrhizae was 6.5%, and the drying tempera- ture and time were 60 ℃ and 8 hours. Conclusion ： The study provides part scientific supports for processing Fructus Evodiae with Radix Glycyrrhizae.

关 键 词：正交设计法 甘草 吴茱萸 

分 类 号：R284.3[医药卫生—中药学]