经典与非经典抗精神病药对流浪乞讨精神分裂症患者临床疗效对比  

Contrast of Clinical Efficacy to Vagrant Patients with Schizophrenia by Typical and Atypical Antipsychotic Drugs

作　　者：甄庆伟 孙佳文[1] 

机构地区：[1]中国.河北省唐山市截瘫疗养院,063000

出　　处：《中国健康心理学杂志》2013年第2期175-176,共2页China Journal of Health Psychology

摘　　要：目的探讨经典与非经典抗精神病药对流浪乞讨精神分裂症患者临床疗效及安全性的影响。方法将我院救治的324例流浪乞讨精神分裂症患者随机分为研究组和对照组各162例,研究组使用各型非经典抗精神病药,对照组使用各型经典抗精神病药。两组均按常规治疗剂量用药。疗程12周,使用阳性与阴性症状量表(PANSS)和副反应量表(TESS)于治疗初,治疗2,4,6,8,12周对临床疗效及各种副反应情况进行评定。观察过程中因其它情况致脱落病例按随机原则补充新病例。结果治疗初两组PANSS无显著差异,均表现出严重精神症状,研究组自2周时开始改善(t=6.78,P<0.01),持续改善至疗程结束(t=26.59,P<0.01)。对照组自6周时出现改善(t=6.89,P<0.01),各周分值改善程度均明显差于研究组(t=6.96,13.53,14.55,21.76,24.24;P<0.01)。研究组TESS于观察各周明显优于观察组(t=7.10,15.56,10.52,18.54,20.23;P<0.01)。结论非经典抗精神病药治疗流浪乞讨精神分裂症患者的临床疗效好安全性高,明显优于经典抗精神病药。Objective To explore clinical efficacy and safety in vagrant patients with schizophrenia by typical and atypical antipsychotic drugs.Methods A total of 324 vagrant patients with schizophrenia were divided randomly into study and control group,typical antipsychotic drugs were used in control group and atypical antipsychotic drugs were used in study group.The drugs were used according to conventional therapeutic dose in both groups for 12 weeks.And we evaluated clinical efficacy and side reaction by PANSS and TESS before treatment and at the time of 2,4,6,8,12 weeks.To add new cases randomly in research process to replace shedding cases.Results The difference of PANSS value was no significant in two groups before treatment（t=0.57,P0.05）.The value began to improve at 2 weeks in study group（t=6.78,P0.01）and continued to the end of treatment（t=26.59,P0.01）.The value began to improve at 6 weeks（t=6.89,P0.01）in control group and was significant difference compared to study group in each week（t=6.96,13.53,14.55,21.76,24.24;P0.01）.The value of TESS in study group was superior to that in control group in each week（t=7.10,15.56,10.52,18.54,20.23;P0.01）.Conclusion Atypical antipsychotic drugs were significantly superior to typical antipsychotic drugs on clinical efficacy and safety in vagrant patients with schizophrenia.

关 键 词：流浪乞讨精神分裂症患者 非经典抗精神病药 经典抗精神病药 临床疗效 

分 类 号：R971[医药卫生—药品]