利拉鲁肽对2型糖尿病患者血浆网膜素影响的研究  

Effect of liraglutide on plasma omentin levels in patients with type 2 diabetes mellitus

作　　者：何煦[1] 杨刚毅[1] 李伶[2] 李钶[1] 李生兵[1] 陈文雯[1] 

机构地区：[1]重庆医科大学附属第二医院内分泌科,400010 [2]重庆医科大学检验系临床生化教研室和教育部实验诊断重点实验室

出　　处：《中国糖尿病杂志》2013年第2期100-102,共3页Chinese Journal of Diabetes

基　　金：国家自然科学基金项目(30771037;30871199;30971388;81070640)

摘　　要：目的探讨T2DM患者血浆网膜素水平的变化及利拉鲁肽治疗对网膜素水平的影响。方法采用酶联免疫法测定T2DM患者及正常人血浆网膜素水平,分析血浆网膜素水平与BMI、WHR、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞分泌指数(HOMA-IS)、FFA等的关系,观察利拉鲁肽治疗前后T2DM患者血浆网膜素水平的变化。结果 T2DM患者血浆网膜素水平明显低于正常人[(19.3±3.9)vs(26.4±6.0)μg/L,P<0.01]。T2DM患者血浆网膜素水平与FIns、HOMA-IR呈负相关(r=-0.41,P<0.05和r=-0.56,P<0.01)。T2DM患者经利拉鲁肽治疗后WHR、BMI、FPG、2hPG和HbA1c均显著降低(P均<0.01),而HOMA-IS则显著增高(P<0.01),空腹血浆网膜素水平也显著增高[(19.3±3.9)vs(21.2±3.8)μg/L,P<0.01]。结论利拉鲁肽能有效改善T2DM患者糖代谢和IS,同时升高血浆网膜素水平。Objective To investigate the effect of liraglutide on plasma omentin levels in patients with T2DM.Methods Plasma omentin levels were measured by ELISA in patients with T2DM and normal controls.The relationships of omentin levels with BMI,WHR,HOMA-IR,HOMA-IS,and FFA were analyzed.After liraglutide treatment,plasma omentin levels were observed in T2DM patients.Results Fasting plasma omentin levels were significantly lower in T2DM patients than in normal controls [（19.3±3.9） vs（26.4±6.0） μg/L,P0.01].Fasting plasma omentin levels in T2DM patients were correlated negatively with FIns and HOMA-IR（r=-0.41,P0.05 and r=-0.56,P0.01）.After liraglutide treatment,WHR,BMI,FPG,2 hPG and HbA1c were significantly decreased（all P0.01）,and HOMA-IS levels were significantly increased in T2DM patients（P0.01）,whilst fasting plasma omentin levels were also significantly increased [（19.3±3.9） vs（21.2±3.8） μg/L,P0.01].Conclusion Liraglutide can remarkably improve glucose metabolism and insulin sensitivity in T2DM patients,and also increase plasma omentin levels.

关 键 词：网膜素 糖尿病 2型 利拉鲁肽 

分 类 号：R587.1[医药卫生—内分泌]