中国汉族血管紧张素转换酶基因多态性与糖尿病肾病相关性的Meta分析  

Meta-analysis: Association of angiotensin converting enzyme gene insertion(I),deletion(D) polymorphism with diabetic nephropathy in Chinese Han population

作　　者：龙爱梅[1] 左彦方[1] 黄晓青[1] 沈明静[1] 

机构地区：[1]广东省深圳市龙岗中心医院内分泌科,深圳518116

出　　处：《中国糖尿病杂志》2013年第2期118-121,共4页Chinese Journal of Diabetes

基　　金：深圳市科技计划项目资助(201103266);深圳市龙岗区科技发展资金医疗卫生项目(2011169)

摘　　要：目的评估中国汉族T2DM患者ACE基因内含子16插入(I)/缺失(D)多态性与DN间的相关性。方法应用RevMan 5软件对21项关于ACE基因插入/缺失多态性与DN关联性的相关研究进行分析,共纳入DN患者2189例,无DN的T2DM患者2160例。结果各研究间具有明显的异质性(P<0.05),随机效应模型分析结果显示,II基因型发生DN的OR值为0.63[95%CI(0.50～0.81)]。结论在中国汉族T2DM患者中,ACE基因的插入(I)多态性,纯合子基因型对个体DN的风险具有保护性作用。Objective To investigate the association between angiotensin converting enzyme gene insertion（I）,deletion（D） polymorphism and diabetic nephropathy.Methods A meta-analysis of 21 studies comprising 2189 cases and 2160 control subjects for investigating the association between the angiotensin converting enzyme insertion/deletion polymorphism and diabetic nephropathy was performed with the software RevMan version 5.Results There was strong evidence of heterogeneity（P0.05）,and a random effects model was employed to summarize the data.An overall random effects OR of 0.63（95%CI 0.50~0.81） was found for II versus DD＋DI genotype.Conclusion Angiotensin converting enzyme gene insertion（I）,deletion（D） polymorphism may represent a modest but significant protection of Chinese T2DM patients from diabetic nephropathy.There is a reduced risk of diabetic nephropathy in II vs other genotypes.

关 键 词：血管紧张素Ⅰ转换酶 基因多态性 糖尿病性肾脏疾病 META分析 汉族 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]