血清胱抑素C、尿NAG、尿微量白蛋白/肌酐比值联合检测对早期糖尿病肾病的价值  

Significance of Serum Cystatin C、Urine NAG、Ratio of Urine Microalbumin to Creatinine for Diagnosing Early Renal Impairment in Patients with Diabetes Mellitus

作　　者：王伟[1] 张卫群[1] 李闯[1] 

机构地区：[1]新乡医学院第三附属医院检验科,河南新乡453003

出　　处：《中国伤残医学》2013年第2期31-32,共2页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨血清胱抑素C(CysC)、尿N-乙酰-β-D氨基葡萄糖苷酶(简称NAG)、尿中微量白蛋白(mAlb)与肌酐(Cr)比值对诊断糖尿病早期肾损害的临床价值。方法:选择尿蛋白阴性的糖尿病患者68例,以健康体检人群95例为对照,采用胶体金免疫比浊法测定血清CysC含量,两点法测尿NAG、免疫比浊法测定尿mAlb含量,酶法测定血清Cr和尿Cr。计算尿mAlb/尿Cr。结果:糖尿病组的血清CysC、尿NAG、尿mAlb/尿Cr测定结果均高于对照组(P<0.05)。而血Cr在2组中差异无统计学意义(P>0.05)。血清CysC、尿NAG、尿mAlb/尿Cr3者联合检测用于糖尿病早期肾损伤比单项有着更高的诊断价值。结论:针对尿蛋白阴性的糖尿病患者,联合检测血CysC、尿NAG、尿mAlb/尿Cr指标,诊断率更高且方便快速,适合广泛推广。Objective： To evaluate the applicability of serum cystatin C（ Cys C） ,urine NAG, ratio of urine microalbumin（ mAlb） to creatinine（Cr） for diagnosing early renal impairment in patients with diabetes mellitus. Methods： The concentration of serum Cystatin C was measured by colloidal gold immunoturbidimetric method , urine mAlb was measured by immune turbidimetry method , urine NAG was measured by 2-point method , the urine micro-malbumin was measured by immunoturbidimetric method, the concentration of serum creatinine and urine creatinine were measured by enzyme method by automatic chemisty analyzer in 68 cases of hypertension patients and 95 cases of health adults.Results：The concentration of Cys C ,urine NAG, ratio of urine mAlb to creatinine in diabetes mellitus group were higher than those in health control group, and there had statistical differences between the two groups（ P 〈 0. 05） ,but no statistical significance about the concentration of serum Cr（ P 〉 0. 05） . Serum Cys C ~urine NAG, ratio of urine mAlb to urine urine creatinine joint detect have higher diagnostic value than individual testing .Conclusions：The negative result of qualitative urine protein could not exclude early renal impairment. Through serum Cys C , urine NAG, urine mAlb / Cr index detection, there should have more important clinical significan for diagnosing early renal damage with diabetes mellitus.

关 键 词：糖尿病 肾损害 胱抑素C 尿NAG 尿微量白蛋白/尿肌酐 

分 类 号：R587[医药卫生—内分泌]