针刺轻度认知障碍患者人中穴的静息态功能磁共振研究  

Study of Resting-state fMRI in Acupuncture at DU26 Point in Patients with Mild Cognitive Impairment

作　　者：陈尚杰[1] 徐茂盛[1] 彭旭明[2] 黄居科[1] 杨文德[1] 许琼瑜[1] 朱芬[1] 石学敏[3] 

机构地区：[1]深圳市宝安人民医院,广东深圳518101 [2]广州中医药大学,广东广州510405 [3]天津中医药大学,天津300193

出　　处：《云南中医学院学报》2013年第1期5-7,共3页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：广东省自然科学基金(NO:10451810101005862);深圳市宝安科技计划(NO:2010720)

摘　　要：目的明确基于认知疾病状态下的针刺人中穴对认知脑功能连接的影响。方法选取了6例合格受试的轻度认知障碍患者,在针刺人中穴的前后进行了6min静息态扫描,分析脑功能连接变化。结果人中穴针刺后的留针阶段,顶下小叶(IPL)的连接减少,左侧背外侧前额叶皮质(DLPFC)的相关连接明显减少;但双侧DLPFC的连接增加,并且右侧DLPFC增加了与右侧IPL、右侧额皮质(frontal cortex)的连接;右侧前额皮质前部(aPFC)增加了与左侧aPFC、左侧IPL及背侧前扣带回/内侧额上回(dACC/msFC)的联系;腹内侧前额叶皮层(VMPFC)增加了与右侧颞顶联合区(TPJ),前岛/额叶岛盖(al/fo),左侧中颞叶(midtemporal)的连接。没有发现晕针、滞针、弯针、血肿等情况,也没出现其他特殊不良反应。结论人中穴行针后的留针阶段,有认知和情绪等多方面的脑功能连接变化。Objective To clarify influence on brain cognitive functional connection of acupuncture at DU26 based on cognitive impairment. Methods Needling at DU26 was performed in six subjects. 6 min of scanning at rest were adopted before and after acupuncture at different acupoints. Changes of brain functional connection were observed. Results During needle retaining of acupueuntnre DU26, trends toward decrease in the connections of the IPL, left DLPFC, but toward increases in the connections of the right DLPFC with left DLPFC, right IPL, right frontal cortex, connections of the right aPFC with left aPFC, connections of the left IPL and dACC/msFC, VMPFC with TPJ, al/fo, left midtemporal. There are no fainting on acupuncture, sticking of the needle, bending of the needle, hematoma and other bad effects. Conclusion During needle retaining of acupucunture DU26, brain areas related to cognitive and emotional were activated.

关 键 词：针刺 人中穴 穴位特异性 轻度认知障碍 功能磁共振 

分 类 号：R246.6[医药卫生—针灸推拿学]