尿微量白蛋白在高血压和糖尿病肾病早期诊断中意义  

Microalbuminuria in High blood pressure and Diabetes nephrosis early diagnosis of significance

作　　者：范世珍[1] 陈安彬[1] 林松青[1] 

机构地区：[1]湖南中医药大学附属深圳市福田区中医院检验科,广东深圳518034

出　　处：《中国实验诊断学》2013年第2期304-306,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨尿微量白蛋白在高血压和糖尿病肾病早期诊断中的意义。方法将研究对象分为单纯高血压病/单纯糖尿病组、高血压合并糖尿病组、糖尿病肾病组及健康对照组,采用免疫透射比浊法检测尿中微量白蛋白的含量,采用尿素酶法检测血清中尿素氮(BUN)的含量,速率法检测血清中肌酐(Scr)的含量,并进行相关性分析。结果尿mALB在单纯高血压、单纯糖尿病和高血压合并糖尿病时,即已明显升高,P<0.05,差异有统计学意义。糖尿病肾病时,尿mALB已远远高于健康对照组,P<0.01,差异有显著统计学意义。而BUN和Scr只有当疾病发展到糖尿病肾病时,才明显升高,与健康对照组比较P<0.01,差异有显著统计学意义。结论肾功能损害与高血压和糖尿病有关,尿微量白蛋白是肾脏早期损害的一个敏感指标,其敏感性高于BUN、Scr,因此检测尿微量白蛋白对高血压和糖尿病肾病的早期诊断有重要意义。Objective microalbuminuria in high blood pressure and diabetes nephrosis early diagnosis of signifi- cance. Methods the research object will be divided into pure hypertension diabetes, high blood pressure of pure/with diabetes mellitus group,diabetic nephropathy group and healthy controls,and by immune method to detect urine than turbidity trace albumin,the content of the urea enzymatic detection serum urea nitrogen （BUN） content, alkaline Gu- WeiSuan method to detect serum muscle （Scr） content of the liver,and the correlation analysis. Results When the u rine mALB simple hypertension,diabetes and high blood pressure alone with diabetes,already significantly higher, P〈 0.05 ,statistically significant differences. Diabetic nephropathy,the urine mALB has much higher than the healthy con- trol group,P〈0.01 ,the difference was statistically significant. BUN and Scr is only when the disease progression to di- abetic nepbropathy, was significantly higher compared with the healthy control group,P〈0.01, the difference was sta tistically significant. Conclusion kidney damage and high blood pressure and diabetes related,microalbuminuria kidney early damage a sensitive indicator, so microalbuminuria detection of high blood pressure and diabetes inthe early diag- nosis of kidney disease to have the important meaning.

关 键 词：尿微量白蛋白 高血压 糖尿病肾病 血肌酐 尿素氮 

分 类 号：R544.1[医药卫生—心血管疾病] R587.2[医药卫生—内科学]