水陆二仙丹对阿霉素肾病大鼠蛋白尿影响的实验研究  

Experimental Study on Influence of Shuiluerxian Pellet to Adrianmycin-inducded Nephropathy Rat's Proteinuria

作　　者：金劲松[1] 盛磊[1] 姜楠[1] 吴兵兵[1] 陈树和[1] 郭向东[1] 

机构地区：[1]湖北省中医院肾内科,湖北武汉430061

出　　处：《湖北中医药大学学报》2013年第1期14-17,共4页Journal of Hubei University of Chinese Medicine

基　　金：湖北省自然科学基金(编号:2007ABA120)

摘　　要：目的观察水陆二仙丹水提取液对阿霉素肾病大鼠蛋白尿的影响。方法 Wistar大鼠随机分为正常组、模型组、水陆二仙丹高、低剂量组、苯那普利组,采用阿霉素尾静脉注射法制作肾病综合征模型。检测24h尿蛋白定量(24hUPQ)、尿β2微球蛋白(β2-MG)、白蛋白(ALB)、免疫球蛋白G(IgG)及血肌酐(Scr)、尿素氮(Bun)、ALB、总蛋白(TP)、甘油三酯(TG)、和胆固醇(CHOL);肾组织切片在电镜、光镜下观察其病理学形态。结果治疗3周后,水陆二仙丹高、低剂量组24hUPQ、尿ALB、β2-MG和IgG定量均显著低于模型组(P<0.01);ALB、TP均显著高于模型组(P<0.01);TG、CHOL显著低于模型组(P<0.01)。结论水陆二仙丹能减轻阿霉素肾病大鼠病理损伤、降低蛋白尿,且在改善营养状况、调节蛋白质及脂质代谢方面有良好作用。Objective To explore the effects of abstracted Liquid of Shuiluerxian Pellet on proteinuria of Adrianmycin-inducded nephropathy rats.Methods Wistar rats were divided at random into five groups：the normal group,the model group,the high-dosed group,the low-dosed group and the Bennazepril group.The nephritic syndrome model was made by injecting Adrianmycin once into the tail vein of the rat.Check 24 hours urine protein quantity（24hUPQ）,urine β2 microglobulin（β2-MG）,urine albumin（U-ALB）and urine immunoglobulin G（IgG）,serum creatinine（Scr）,blood urea nitrogen（BUN）,serum albumin（ALB）,serum total protein（TP）,triglycerides（TG）and cholesterol（CHOL）.Kidney tissues were observed by light and electron microscope.Results After 3-week treatment,in the high-dosed,low-dosed groups 24hUPQ,U-ALB,β2-MG and IgG of the rats were significantly lower than those in the model group（P0.01）,and the severity of pathological lesions in the rats was decreased;the serum level of ALB and TP was higher than that in the model group（P0.01）;the content of TG and CHOL was significantly lower than that in the model group（P0.01）.Conclusion Shuiluerxian Pellet could relieve the degree of pathological lesions of Adrianmycin-induced nephropathy rats,and reduce the Proteinuria.In addition,Shuiluerxian Pellet has good function of improving on the nutriture,as well as regulating the protein and lipid metabolism.

关 键 词：肾病综合征 水陆二仙丹 蛋白尿 

分 类 号：R285.5[医药卫生—中药学]