苯磺酸左旋氨氯地平和硝苯地平缓释片对原发性高血压患者血压变异率和颈动脉内膜中层厚度的影响  

Effect of Levamlodipine besylate and nifedipine sustain-released tablets on blood pressure variety ratio and carotid intima media thickness in patients with primary hypertension

作　　者：关良劲[1] 钟汉林[1] 李雅茜[1] 苏梦达 黄艳[1] 

机构地区：[1]广东省广州市天河区中医医院,广东广州510655

出　　处：《现代中西医结合杂志》2013年第7期691-692,702,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的比较苯磺酸左旋氨氯地平和硝苯地平缓释片对原发性高血压(EH)患者血压变异率和颈动脉内膜中层厚度的影响,探讨其血压变异率和颈动脉内膜中层厚度变化的相关性。方法将有颈动脉内膜中层增厚的80例EH患者随机分成2组,每组40例。A组服用苯磺酸左旋氨氯地平,B组服用硝苯地平缓释片,均服用3个月后观察2组患者血压变异率和颈动脉内膜中层厚度的变化,评价其血压变异率和颈动脉内膜中层厚度变化的相关性。结果 A组血压变异率低于B组(P<0.05),颈动脉内膜中层厚度明显降低,而B组颈动脉内膜中层厚度无明显变化;苯磺酸左旋氨氯地平对血压变异率的影响和对颈动脉内膜中层厚度影响呈正相关。结论苯磺酸左旋氨氯地平能很好地控制EH患者血压变异率,能降低颈动脉内膜中层厚度,且其变异率的改变和颈动脉内膜中层厚度的改变呈正相关。Objective It is to compare the effects of Levamlodipine besylate and nifedipine sustain-released tablets on blood pressure variety ratio （BPVR） and carotid intima media thickness （CIMT） in patients with essential hypertension （EH） , and to explore the correlation between BPVR and CIMT. Methods 80 cases of patients with EH complicating with in- creased CIMT were randomly divided into 2 groups with 40 cases in each group. Group A was given Levamlodipine besylate and group B was given nifedipine sustain-released tablets. The changes of CIMT and BPVR were observed in both groups after 3 months＇treatment, and the correlation between them was evaluated. Results BPVR was lower in group A than that in group B（P 〈 O. 05 ）. CIMT decreased obviously in group A, but no significant change was found in group B. Levamlodipine besylate had a positive correlation with BPVR and CIMT. Conclusion Levamlodipine besylate can well control the BPVR and decrease CIMT of patients with EH, the changes of BPVR is positive related with the changes of CIMT.

关 键 词：苯磺酸左旋氨氯地平 硝苯地平缓释片 原发性高血压 颈动脉内膜中层厚度 血压变异率 

分 类 号：R544.1[医药卫生—心血管疾病]