应激导致抑郁症与单胺类递质系统稳态  

Stress induced depression and monoaminergic system homeostasis

作　　者：陈洁[1] 黄宏平[1] 

机构地区：[1]皖南医学院细胞电生理研究室,芜湖241002

出　　处：《生物学杂志》2013年第1期78-81,共4页Journal of Biology

基　　金：国家自然科学基金(30770674);安徽省第四批优秀青年基金(08040106817);皖南医学院博士启动基金(201206)

摘　　要：当机体受到各种应激刺激时,机体会产生一系列特异性和非特异性反应,使机体的生理功能维持在新的稳态。如果应激持续时间过长,或者程度过于强烈,超过了机体稳态调节的范围,应激刺激就会对机体生理功能的稳态产生破坏。与应激相关的精神障碍不仅抑郁症一种,应激影响单胺类递质系统造成抑郁症可能主要是影响了5-HT递质系统的功能,而对NE递质系统或DA递质系统造成的影响不是导致抑郁症发病的主要原因。应激除了改变神经系统,还会影响机体内分泌系统,免疫系统,使抑郁症病人的发病和临床症状极为复杂。主要综述应激,特别是长期的、慢性的应激引起单胺能神经递质系统改变,进而导致抑郁症的神经生物学机制研究进展。The stressful event is an important factor leading to depression. Stress refers to the specific and/or non-specific reaction when body homeostasis is threatened to maintain the body at a new steady state. Stress response is benefit when it is in short duration, but it is harmful and disruptive when it lasts for a long period. Stress can induce depression when it changes the function of central monoaminergic transmitter system. Stress also influences endocrinology system and immunology system other than nervous system, it makes the pathophysiology and clinic syndrome more complicity. This review illustrated the correlation between the long-term, chronic stress and depression pathogenesis mainly focusing on the monoaminergic neurotransmitter system.

关 键 词：应激 单胺类递质系统 稳态 抑郁症 

分 类 号：Q189[生物学—神经生物学]