普米克令舒联合博利康尼氧气雾化吸入治疗小儿毛细支气管炎的临床研究  

Budesonide combined with terbutaline oxygen atomization inhalation to treat bronchiolitis clinical research

作　　者：靳曼丽[1] 

机构地区：[1]河南省商丘市第一人民医院小儿科,476100

出　　处：《中国现代药物应用》2013年第3期10-11,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨普米克令舒联合博利康尼氧气雾化吸入治疗小儿毛细支气管炎临床疗效。方法 2010年05月至2012年05月收治的毛细支气管炎170例,分为常规组85例,治疗组85例,观察两组临床疗效。结果治疗组总有效率95.29%,常规组总有效率70.58%,两组总有效率比较P<0.01为差异有统计学意义。结论急性毛细支气管炎是2岁以下儿童多发疾病,主要病原体为呼吸道合胞病毒,少数由流感病毒、腺病毒、人类3型副流感病毒等感染引起。主要病变部位为广泛毛细支气管炎症,支气管黏膜水肿、形成气道狭窄、气管痉挛从而引起临床表现为发作性喘憋;控制喘憋是治疗毛细支气管炎主要措施。布地奈德具有较强的抑制变态反应及非特异性抗炎作用,小剂量就能够达到所需临床疗效;博利康尼雾化溶液是肾上腺素β2受体激动药,经雾化气道给药,可以使药物作用更加直接,均匀分布肺组织内;总之,小儿毛细支气管炎采取氧气驱动雾化吸入普米克令舒联合博利康尼能够及早控制症状,显著缩短病程,促进疾病康复。Objective To investigate the Pulmicort combined bricanyl oxygen atomization inhalation to treat bronchiolitis clinical curative effect. Methods From May 2010 to May 2012 from 170 cases of bronchiolitis, divided into routine treatment group 85 cases, 85 cases in treatment group, two groups of clinical curative effect observation. Results The total effective rate of treatment group and routine group 95.29%, the total effective rate was 70. 58%, total effective rate between the two groups have significant difference at P 〈 0. 01. Conclusion Acute bronchiolitis in children under 2 years of age with multiple diseases, major pathogen for re- spiratory syncytial virus, influenza virus, the minority by adenoviruses, human parainfluenza virus type 3 infection caused by. The primary lesion site for a wide range of bronchiolitis disease, bronchial mucosal edema, formation of airway stenosis, tracheal spasm causing clinical manifestations of paroxysmal wheezing; control treatment of bronchiolitis wheezing is main measure. Budesonide has strong inhibiting allergic reaction and nonspe- cific anti-inflammatory effect, small dosage to achieve a desired clinical efficacy; Brincanyl aerosol solution is adrenergic β2 receptor agonist, the atomizing inhalation, can make the drug effect is more direct, uniform distribution in the lung tissue of; In conclusion, pediatric bronchiolitis take oxygen drive atomization inhalation of Pulmicort combined with Boli Connie to early control of symptoms, shorten the course of disease, promoting disease rehabilitation.

关 键 词：普米克令舒联合博利康尼雾化吸入 毛细支气管炎 临床研究 

分 类 号：R725.6[医药卫生—儿科]