阻塞性睡眠呼吸暂停低通气综合征患者血清C反应蛋白和白细胞介素水平的变化及意义  

作　　者：李胜利[1] 

机构地区：[1]广东省东莞市人民医院呼吸科,523000

出　　处：《当代医学》2013年第6期7-9,共3页Contemporary Medicine

摘　　要：目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)血清C反应蛋白(CRP)和白细胞介素(6IL-6)水平的变化及其意义。方法选择诊治的32例OSAHS患者,采用ELISA法检测血清CRP和IL-6的水平,并与30例对照组进行比较分析。结果 OSAHS组患者血清CRP和IL-6的水平明显高于对照组,两组比较差异有统计学意义(P<0.05);且CRP和IL-6与呼吸暂停低通气指数(AHI)呈正相关(r=0.768,P<0.01);与脉搏血氧饱和度呈负相关(r=-0.816,P<0.01)。结论 CRP和IL-6与OSAHS密切相关,对于阐明睡眠相关因子在OSAHS发病机制中的作用及其变化规律有着重要意义。Objective To investigate the level changes and significance of C reaction protein（CRP）and interleukin 6（IL-6）in obstructive sleep apnea hypopnea syndrome（OSAHS）. Methods 32 cases of OSAHS were selected, serum level of CRP and IL-6 were detected with ELISA assay and compared with control group of 30 cases. Results Serum CRP and IL- 6 level in OSAHS patients were obviously higher than that of control group, there was significant difference between the two groups（P〈0.05）. CRP and IL-6 and apnea low air index （AHI） were positively correlated （r = 0.768,P〈0.01）.Minimum refers to pulse oxygen saturation （SaO 2） was negatively correlated （r = -0.816,P〈0.01）. Conclusion CRP and IL - 6 is closely related with OSAHS,it has important significance to clarify the related sleep factor in the OSAHS on mechanism of action and its change rule.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 C反应蛋白 白细胞介素6 

分 类 号：R56[医药卫生—呼吸系统]