不同HBV感染模式产妇血清及乳汁HBV-DNA检测结果分析  

HBV-DNA level analysis in serum and breast milk of puerpera with different HBV infection modes

作　　者：李文郎 刘卫东 吴爱成 唐恒锋 

机构地区：[1]广东省深圳市观澜人民医院检验科,广东深圳518110

出　　处：《国际检验医学杂志》2013年第4期400-401,共2页International Journal of Laboratory Medicine

摘　　要：目的了解不同乙型肝炎病毒(HBV)感染模式产妇血清及乳汁HBV-DNA的载量以及两者之间的关系。方法对385例血清乙肝指标阳性的产妇,应用荧光定量法检测血清和乳汁中的HBV载量,根据产妇HBV血清标志物模式不同分为4组,分析各组血清与乳汁中HBV-DNA含量的关系。结果 A组(HBsAg、HBeAg、HBcAb均为阳性)乙肝大三阳产妇血清和乳汁HBV-DNA阳性率为分别为94.1%和69.4%,明显高于其他模式(P<0.01),且其病毒载量也显著高于其他组;B组(HBsAg、HBeAg为阳性)产妇血清和乳汁HBV-DNA阳性率为分别为90.9%和61.5%,明显高于C组(HBsAg、HBeAb、HBcAb为阳性)和D组(HBsAg、HBcAb为阳性),P<0.01,且其病毒载量也显著高于C组和D组。结论产妇血清中HBV-DNA水平的高低与乳汁中HBV-DNA呈正相关关系。Objective To explore the hepatitis B virus（HBV） DNA loads in serum and breast milk of puerperal with difterent HBV infection models and the relationship between them. Methods 385 cases of puerpera with positive HBV markers were divided into 4 groups according to the HBV infection models and detected by fluorescence quantitative assay for the HBV DNA loads in ser- um and breast milk. The relationship between the HBV DNA loads of serum and breast milk was analyzed. Results In group A, the positive rates of HBV DNA in serum and breast milk were 94.1% and 69.4 %, significantly higher than those in other groups（ P〈0 0.01） ,and the HBV DNA load was significantly higher than those in other groups. In group B,the positive rates of HBV DNA in serum and breast milk were respectively 90.9 % and 61.5 %, significantly higher than those in group C and group D（P〈 0.01 ）, and the HBV DNA load was significantly higher than those in group C and group D. Conclusion There might be positive correlation between HBV levels in serum and breast milk of puerpera.

关 键 词：肝炎病毒 乙肝 DNA 病毒 血清 乳汁 母乳喂养 

分 类 号：R714.25[医药卫生—妇产科学]