血胱抑素C、视黄醇结合蛋白与尿微量清蛋白/肌酐联合检测在早期肾损伤中的诊断价值  

Diagnostic value of serum cystatin C,retinol binding protein and microalbuminuria/creatinine in early renal damage

作　　者：薛邦禄[1] 李妍[1] 徐维家[1] 

机构地区：[1]辽宁省大连市中心医院检验科,116033

出　　处：《国际检验医学杂志》2013年第4期425-426,429,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨血清胱抑素C(Cys C),视黄醇结合蛋白(RBP)与尿微量清蛋白/肌酐(mAlb/Cr)联合检测在早期肾损伤诊断中的应用价值。方法根据24h尿蛋白定量分为A组和B组:A组43例,尿蛋白<150mg/24h,尿蛋白定性为阴性;B组63例,尿蛋白150～300mg/24h,尿蛋白定性为弱阳性或阳性。以尿常规作尿蛋白定性测定后,检测mAlb及Cr,通过计算得出mAlb/Cr比值;同时空腹采血,检测血清Cys C和RBP。结果 A组血清Cys C、RBP和尿mAlb/Cr明显高于健康对照组(P<0.01),B组血清Cys C、RBP和尿mAlb/Cr明显高于A组(P<0.01)。A、B两组3项联合检测阳性率显著提高,血清Cys C、RBP和尿mAlb/Cr呈明显正相关。结论血清Cys C、RBP和尿mAlb/Cr是诊断早期肾损伤的敏感指标,联合检测具有较高的临床应用价值。Objective To study the application value of serum cystatin C（CysC）,retinol binding protein（RBP） and microalbu- minuria/creatinine（mAlb/Cr） combined detection in the diagnosis of early renal damage. Methods According to the 24-hour urina-ry protein quantitation the patients were divided into group A（urine protein〈150 mg/24 h for negative） and group B（urine protein 150-300 mg/24 h for positive or weak positive）. Routine detection of urine microalbuminuria and urine creatinine was performed to calculate the ratio of mAlb and Cr. At the same time,serum CysC and RBP were tesed. Results The serum CysC,RBP and urine mAlb/Cr of group A was significantly higher than control group（P〈0.01） and those of group B were significantly higher than group A（P〈0.01）. The combined detection of the three indexes greatly improved detection rate in group-A and B. The serum Cy-sC,RBP and urine mAlb/Cr had significantly positive correlations. Conclusion The serum CysC,RBP and urine mAlb/Cr could be sensitivity indexes for the early renal damage. The combined detection mitht have very higher value for clinical diagnosis.

关 键 词：半胱氨酸蛋白酶抑制剂 视黄醇结合蛋白质类 白蛋白尿 肌酐 肾 早期诊断 

分 类 号：R692[医药卫生—泌尿科学]