基于血清异常激素的多囊卵巢综合征中医证候研究  

Research of polycystic ovarian syndrome TCM syndromes based on serum abnormal hormones

作　　者：刘新敏[1] 刘睿[2] 艾莉[1] 文胜[1] 周雪忠[3] 马兰[2] 李文[2] 徐信[2] 王燕[1] 刘莹[1] 李艳红[1] 

机构地区：[1]中国中医科学院广安门医院妇科,北京100053 [2]北京中医药大学针灸推拿学院 [3]北京交通大学计算机与信息技术学院

出　　处：《环球中医药》2013年第1期12-15,共4页Global Traditional Chinese Medicine

基　　金：国家自然科学基金(81072839);中国中医科学院优势病种课题(CACMS08Y006)

摘　　要：目的探讨多囊卵巢综合征(PCOS)血清异常激素与中医证候的相关性。方法记录240名多囊卵巢综合征患者的血清睾酮(T)、促黄体素(LH)、胰岛素、月经情况、症状、舌象、脉象等,进行中医辨证,分别统计异常激素的证候频次,用Logistic多元回归分析探讨异常血清激素与中医证候的相关性。结果纳入患者中出现频次最多的证候有四型,包括肝肾阴虚证、肾阴虚火旺证、肝胃郁热证、脾虚胃热证,其中,高睾酮出现频次最多的是肾阴虚火旺证,高促黄体素出现频次最多的是肝肾阴虚证,高胰岛素出现频次最多的是肝胃郁热证;高睾酮与肾阴虚火旺证、高促黄体素与肝肾阴虚证和肾阴虚火旺证、高胰岛素与肝胃郁热证和脾虚胃热证均呈显著正相关关系(P<0.01)。结论多囊卵巢综合征异常血清激素与证候有相关性,不同激素的中医病位不同。Objective To investigate the correlation between abnormal serum hormones and TCM syndromes of polycystic ovarian syndrome（PCOS） . Methods TCM syndromes of 240 cases of PCOS were carried out by questionaires including the level of serum testosterone, luteinizing hormone, insulin, symp- toms, tongue picture, pulse condition, menstrual cycle, period, menstrual volume, color,blood clot, dys- menorrhoea, etal. The frequencies of each type of TCM syndromes were statisticed according to the abnor- mal serum hormones. Logistic multiple regression analysis was performed to analyze the correlation of ab- normal serum hormones and TCM syndromes. Results The most four TCM syndromes among the 240 pa- tients are deficiency of liver-yin and kidney-yin, kidney-yin deficiency and hyperactivity of fire, stagnated heat in liver and stomach, and deficiency of spleen and heat of stomach. The most TCM syndrome of high T patients was kidney-yin deficiency and hyperactivity of fire, which of high LH patients was deficiency of liv- er-yin and kidney-yin and of high insulin was stagnated heat in liver and stomach. High T and kidney-yin deficiency and hyperactivity of fire, high LH and deficiency of liver-yin and kidney-yin, high insulin and stagnated heat in liver and stomach and deficiency of spleen and heat of stomach showed significantly posi- tive correlation relationship （ P 〈 0.01 ）. Conclusion Abnormal serum hormone had its relative TCM path- ological position, and was associated with TCM syndrome.

关 键 词：多囊卵巢综合征 证候研究 血清激素 相关性 

分 类 号：R271.9[医药卫生—中西医结合]