雅培化学发光法在HIV筛查试验中假阳性分析  

Evaluation of the False-positive of Abbott Chemiluminescence Immunoassay in HIV Screening Test

作　　者：张晓红[1] 张倩[1] 周学红[1] 耿红艳[1] 

机构地区：[1]首都医科大学附属北京同仁医院检验科,北京100730

出　　处：《标记免疫分析与临床》2013年第1期43-46,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的分析雅培化学发光法在HIV筛查试验中的假阳性。方法对本院2011年8月至2012年3月期间所有术前检查病人通过雅培化学发光法进行HIV筛查试验检测。结果 39076例病人血清标本中,共筛检出阳性血清31例,经北京市疾病控制中心通过免疫印迹法(WB)进行确认后,21例为阳性,6例为不确定,4例为阴性。结论雅培化学发光法HIV抗原抗体联合检测假阳性率(12.90%)较高,因此仍应结合临床资料及确认试验结果综合判断。Objective To evaluate the falsepositive of Abbott chemiluminescence immunoassay （CLIA） in HIV screening test. Methods The total 39076 samples from the pre-operation patients （from August 2011 to March 2012） in Beijing Tongren Hospital were tested for HIV screening through the ARCHITECT I2000. Results 31 samples were screened as the anti-HIV positive. After the HIV confirmation test by Beijing Center for Disease Control, 21 samples were diagnosed as the anti-HIV positive, 6 samples were indeterminate and 4 samples were anti-HIV negative. Conclusion The false-positive rate of ARCHITECT HIV Ag/Ab Combo is high （12.90%）, the anti-HIV positive should be diagnosed based on clinical data and HIV confirmation test with regular followup.

关 键 词：化学发光法 人类免疫缺陷病毒 

分 类 号：R446.6[医药卫生—诊断学]