优选延胡索炮制方法  

Preferred different Processing Technology of corydalis yanhusuo

作　　者：林海[1] 容穗华[1] 高妮[2] 

机构地区：[1]广东省中医院,广州510120 [2]广州市医药职业学校,广州510430

出　　处：《海峡药学》2013年第1期37-40,共4页Strait Pharmaceutical Journal

摘　　要：目的比较延胡索不同炮制工艺有效成分的含量,确定最佳的炮制工艺。方法采用HPLC测定延胡索不同炮制品中原阿片碱、盐酸小檗碱和延胡索乙素的含量,采用电位滴定法测定其炮制品中总生物碱的含量,比较不同炮制品有效成分的含量。结果延胡索生品及炮制品的醇提液中3种生物碱的含量均高于水提液,与生品比较,炮制品的水提液中3种生物碱的含量均有不同程度的升高,醇提液中3种生物碱含量则有不同程度的降低,总生物碱也有不同程度的降低。与传统炮制品比较,醋烘法和微波炮制法中水提液的3种生物碱的含量均较高。结论延胡索经醋制和酒制后,水提液中有效成分的溶出率增大,以醋烘法和微波炮制法最佳。OBJECTIVE To investigate the content of main active compositions of Corydalis yanhusuo in dif- ferent processing technology and determine the best processing technology. METHODS HPLC was used to de- termine the content of Protopine, Berberine and Tetrahydropalmatine, and the content of total alkaloid was deter- mined by the method of potentiometric titration in different processing technology, the content of main active compositions in different processing sample was compared. RESULTS The content of three kind of Alkaloid ex- tracted with methanol in Corydalis yanhusuo and its processed sample was higher than that extracted with water, Compared with Corydalis yanhusuo, the content of three kind of alkaloid extracted with water was increased in varying degrees, the content of three kind of alkaloid extracted with alcohol was reduced in varying degrees, the content of total alkaloids was also reduced in varying degrees. Compared with other processed sample, the content of three kind of alkaloid extracted with water were higher than that in Corydalis yanhusuo processed with the method of baking and microwave. CONCLUSION After processing with vinegar and wine, the dissolution rate of main active compositions extracted with water is increased, and the results show that the best method is processing with baking and microwave.

关 键 词：延胡索 原阿片碱 盐酸小檗碱 延胡索乙素 总生物碱 炮制方法 

分 类 号：R283.3[医药卫生—中药学]