N-苄基苦参酸姜黄素酯的合成  

Synthesis of Curcumin N-Benzyl Matrinate

作　　者：吴素素[1] 刘纯姣[1] 何继慧[1] 吴亚先[1] 何黎琴[1] 

机构地区：[1]安徽中医学院药学院,安徽合肥230031

出　　处：《安徽化工》2013年第1期45-47,共3页Anhui Chemical Industry

基　　金：安徽省高校优秀青年教师基金项目(2012SQRL105);2011安徽中医学院药学院大学生"药苑之星"科研创新专项基金

摘　　要：目的:合成N-苄基苦参酸姜黄素酯并优化其合成工艺。方法:以苦参碱为原料,通过水解开环,苄基化得到N-苄基苦参酸苄酯,继而水解得到N-苄基苦参酸,最后在脱水剂作用下与姜黄素缩合,得到目标物N-苄基苦参酸姜黄素单酯。结果与结论:设计合成了N-苄基苦参酸姜黄素酯,收率达51.3%,产物的化学结构经IR、MS、1H-NMR等表征。Objective： To synthesize curcumin N-Benzyl matrinate and optimize the technical process. Methods：Matrine was reacted with sodium hydroxide giving the hydrolytic ring-opening derivative matrinic acid, which was condensed benzyl chloride to yield N- Benzyl matrinate. The matrinate was hydrolyzed to give N- Benzyl matrinic acid, which was coupled with curcumin in the presence of edci/dmap to provide target compounds. Results and conclusions： The target compound was obtained. Its chemical structure was confirmed by MS, IR, and 1H-NMR spectra. The yield of curcumin N- Benzyl matrinate is 51.3%.

关 键 词：苦参碱 姜黄素 合成 

分 类 号：R284.3[医药卫生—中药学]