原发性高血压老年患者C-反应蛋白、同型半胱氨酸水平变化与颈动脉粥样硬化、左室肥厚关系  

Changes of plasma C-reactive protein and homocysteine levels in elderly patients with essential hypertension and left ventricular hypertrophy or atherosclerosis

作　　者：珠勒皮亚.司马义 陈玉岚[1] 布海力且木.买买提 

机构地区：[1]新疆医科大学第一附属医院高血压科,乌鲁木齐830054 [2]新疆库尔勒市第一人民医院心内科

出　　处：《中国临床保健杂志》2013年第1期1-3,共3页Chinese Journal of Clinical Healthcare

基　　金：国家自然科学基金项目(30960105)

摘　　要：目的探讨原发性高血压老年患者C-反应蛋白(CRP)、同型半胱氨酸(Hcy)水平变化与颈动脉粥样硬化(AS)、左室肥厚(LVH)的关系。方法老年高血压患者285例,行心脏彩色超声检查、CRP及Hcy的测定。根据是否伴随LVH将高血压患者分为LVH组与左室正常组;根据是否伴随颈部AS将高血压患者分为颈动脉内膜正常组和动脉硬化组,动脉硬化组分为颈动脉内膜增厚组和斑块形成组两个亚组。结果LVH组Hcy及CRP水平均高于无LVH组(P<0.05);AS组Hcy及CRP水平均高于内膜正常组(P<0.05)。Hcy及CRP水平与AS或LVH相关(P<0.05)。结论 Hcy及CRP水平与AS或LVH发病具有相关性,两者是老年高血压患者合并LVH或AS的独立预测指标。Objective To investigate the correlation among left ventricular hypertrophy（LVH） or atherosclerosis（AS） and plasma homocysteine（Hcy）,C-reactive protein（CRP） in patients with essential hypertension（EH）.Methods Two dimensional echocardiography,plasma Hcy and CRP were examined in 258 patients with essential hypertension.According to whether concomitant LVH,patients were divided into two groups：LVH group and non-LVH group.According to whether concomitant AS,patients were divided into two groups：AS group（intimal thickening group plaque formation group） and non-AS group.Results The concentrations of plasma Hcy and CRP were higher in LVH group than those in non-LVH group（P0.05）.The concentrations of plasma Hcy and CRP were higher in AS group than those in non-AS group（P0.05）.Plasma Hcy were correlated with As or LVH（P0.05）.CRP were also correlated with As or LVH（P0.05）.Conclusion The concentrations of plasma Hcy and CRP are closely related with LVH or AS,which may suggest that inflammation should be involved in the occurrence and development of LVH.These two factors are independent predictors in elderly hypertensive patients with LVH or AS.

关 键 词：高血压 C反应蛋白质 半胱氨酸 动脉粥样硬化 肥大 左心室 

分 类 号：R544.1[医药卫生—心血管疾病]