硫辛酸对2型糖尿病患者尿8-羟基脱氧鸟苷排泄的影响  

The effect of alpha-lipoic acid on urinary 8-hydroxy-deoxyguanosine excretion in type 2 diabetics

作　　者：林海燕[1] 徐将[1] 叶山东[1] 

机构地区：[1]安徽医科大学附属省立医院安徽省立医院内分泌科,合肥230001

出　　处：《中国临床保健杂志》2013年第1期16-18,共3页Chinese Journal of Clinical Healthcare

基　　金：安徽省自然科学基金(11040606M159);安徽高校省级自然科学研究项目(KJ2011A157)

摘　　要：目的观察α-硫辛酸(ALA)对2型糖尿病患者尿8-羟基脱氧鸟苷(8-OHdG)排泄的影响,探讨其肾脏保护的可能机制。方法选择36例2型糖尿病患者为观察组,在原抗糖尿病治疗的基础上加用ALA,并选择同期健康体检的30例作为对照组。6个月后,观察治疗前后空腹血糖(FBG)、糖化血红蛋白(HbA1c)和尿白蛋白(ALB)及尿8-OHdG水平变化。结果 (1)与对照组比较,糖尿病组尿微量白蛋白/肌酐比值(UACR)及U8CR(尿8-OHdG/Ucr)值明显升高,差异有统计学意义(P<0.01)。(2)与治疗前相比较,ALA治疗后,观察组FBG和HbA1c无明显变化,UACR及U8CR值明显降低,差异有统计学意义(P<0.01)。(3)U8CR水平与UACR显著正相关(r=0.773,P<0.01)。结论α-硫辛酸可以减少2型糖尿病患者尿8-OHdG排泄,减轻体内氧化应激,该作用可能与其肾脏保护部分有关。Objective To observe the effects of Alpha-lipoic acid（ALA） on urinary 8-hydroxy-deoxyguanosine（8-OHdG） excretion in type 2 diabetics and explore its possible reno-protective mechanisms.Methods 36 type 2 diabetics were recruited as the observation group and treated with ALA on the basis of initial therapy,and 30 healthy subjects at the same period were selected as the control group.At the basal and the sixth month after ALA treatment,FBG,HbA1c,urinary 8-OHdG,urinary albumin（ALB） and urinary creatinine（Cr） were determined,respectively.Results Compared with the control group,the urinary 8-OHdG/Cr ratio（U8CR）,urinary albumin/urinary creatinine ratio（UACR） in diabetic patients increased markedly（P0.01）.U8CR and UACR in observation group were significantly decreased after ALA treatment（P0.01）,but no significant changes occurred in FBG and HbA1c.U8CR had positive correlation with UACR（r=0.773,P0.01） in diabetic patients.Conclusion ALA can decrease urinary 8-OHdG excretion and lighten oxidative stress in vivo in type 2 diabetics,which may play a protective role for the kidney injury.

关 键 词：糖尿病肾病 脱氧鸟苷 硫辛酸 氧化性应激 

分 类 号：R587.1[医药卫生—内分泌]