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作 者:汪永玲[1] 孔晓龙[1] 莫凤珍[1] 梁凯[1] 覃振明[1] 朱海瑛[1]
出 处:《中国临床新医学》2013年第2期105-108,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基 金:广西科学研究与技术开发项目(编号:桂科攻10124008-7)
摘 要:目的观察软坚护肝片对SD大鼠的长期毒性。方法将160只大鼠随机分为4组(每组40只),分别为软坚护肝片低剂量组(1.24g/kg)、中剂量组(2.48g/kg)、高剂量组(4.96g/kg)和对照组。给药的三组每日灌胃1次,每周给药6d,连续26周;对照组等体积蒸馏水灌胃。观察大鼠一般状况、体重、摄食量等变化,给药后13、26周及停药后4周时检查大鼠的血液学、血液生化学、脏器系数和组织病理学改变。结果各剂量组动物一般状况良好,血液学、血液生化学及脏器系数与对照组比较差异均无统计学意义(P>0.05),组织病理学检查未见异常改变。结论软坚护肝片在临床剂量范围内毒性小,用药安全。Objective To observe the long-term toxicity of Ruanjian Hugan Tablet (RJHGT) in SD rattus norregicus. Methods One hundred and sixty rattus norregicus were randomly divided into four groups (40 in each group) ;low, moderate ,high dosage groups (groupL, M, H ) and control group (group C ). Experimental groups were given RJHGT by garage, and group C was given distilled water instead. The experiment was carried out for 26 consec- tive weeks. General conditions, body weight, food intake of SD rattus norregicus were observed. Hematology, biochemical parameters, coagulation function, organ coefficient, histopathology changes of SD rattus norregicus were detected in 13 and 26 weeks of the experiment, and in 4 weeks after drug withdrawal. Results All the indexes mentioned abovewere normal in group L, M and H. Conclusion The toxicity of RJHGP is low when it is used in its clinical range, and it is safe.
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