急性冠状动脉综合征患者血清缺血修饰白蛋白水平的变化  

The value of ischemia modified albumin and the protein markers of myocardial injury in acute coronary syndrome

作　　者：王开森[1] 牛爱军[1] 孙晓[1] 张华[1] 胡成进[1] 

机构地区：[1]济南军区总医院实验诊断科,山东济南250031

出　　处：《实用医药杂志》2013年第2期100-102,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的评价缺血修饰白蛋白在急性冠状动脉综合征早期诊断中的意义。方法对笔者所在医院确诊的122例急性冠状动脉综合征患者进行血清缺血修饰白蛋白、肌钙蛋白I(cTnI)、肌酸激酶同工酶(CKMB)、肌红蛋白(MYO)检测,并进行统计分析。结果不稳定型心绞痛和心肌梗死患者血清缺血修饰白蛋白水平均明显低于正常对照组(P<0.01),AMI组与各组血清cTnI、CKMB水平均有显著性差异(P<0.01),与MYO水平无显著性差异(P>0.05)。结论缺血修饰白蛋白是一种较理想的早期诊断心肌缺血的指标,血清缺血修饰白蛋白水平检测对于急性冠状动脉综合征早期诊断及治疗有一定临床价值。Objective To research for the early diagnostic value of ischemia modified albumin （IMA） for acute coronary syndrome （ACS）. Methods Serum IMA, cTnI, CKMB, MYO levels were studied in 122 ACS patients. Results Serum levels of IMA in patients with unstable angina and acute myocardial infarction chest pain were significantly lower than those in normal controls （P〈0.01）. There was significant difference between the AMI and other groups in cTnI, CKMB（P〈0.01）, there were no significantly differences in MYO（P〉0.05）. Conclusion These results suggest that IMA is a good marker in the early diagnosis of myocardial ischemia. The detection of serum levels of ischemia modified albumin has an important value in early diagnosis and treatment of acute coronarv syndromes.

关 键 词：急性冠脉综合征 缺血修饰白蛋白 心肌损伤蛋白标志物 

分 类 号：R541.4[医药卫生—心血管疾病]