岩盐气溶胶疗法对支气管哮喘患者外周血IL-4、IFN-γ、IgE水平的影响及临床疗效分析  

Halotherapy on peripheral blood IL-4,IFN-γ,IgE impact and clinical efficacy in patients with bronchial asthma

作　　者：李红艳[1] 翁恒[1] 王琳[1] 陈力舟[1] 黄艳生[1] 邹盛华 

机构地区：[1]福建医科大学教学医院福建省福州肺科医院呼吸科,福州350008 [2]福建医科大学教学医院福建省福州肺科医院检验科,福州350008

出　　处：《福建医药杂志》2013年第1期70-72,共3页Fujian Medical Journal

基　　金：福州市科技计划项目(2010-S-69)

摘　　要：目的了解岩盐气溶胶疗法(简称盐疗)对支气管哮喘患者的疗效及其对IL-4、IFN-γ和IgE水平的影响,探讨其治疗哮喘的机制。方法随机选择≥14岁初诊支气管哮喘患者40例(包括间歇发作、轻度持续及中度持续患者),其中拒绝吸入治疗的患者25例为观察组,其余15例为对照组,观察组予岩盐气溶胶治疗,对照组按全球哮喘防治创议(GINA)方案给予吸入治疗,连续治疗,观察90d。结果观察组和对照组治疗后,患者外周血IL-4、总IgE水平均明显降低,IFN-γ水平均明显升高,与本组治疗前比较,差异有统计学意义(P<0.05);两组间比较,差异无统计学意义(P>0.05)。结论盐气溶胶疗法能降低血清IL-4、IgE水平,使IFN-γ水平升高,盐疗作为支气管哮喘患者非药物治疗的方法,临床效果好。Objective To evaluate the effectiveness of Halotherapy in patients with bronchial asthma. To explore the changes of IL-4, IFN-7 and IgE. To explore the mechanism of the treatment of asthma. Methods A total of 40 patients older than or equal to 14 years of age with newly diagnosed bronchial asthma were collected in random at Lung Disease Hospital of Fu- jian Fuzhou. Halotherapy group 25 cases were treated with rock salt aerosol treatment. Control group of 15 cases were treated with the inhalation treatment of GINA. All patients were treated continuously for 90 days. Results Halotherapy group patients and control group patients, peripheral blood IL-4, IgE were significantly lower than before treatment, IFN 7 were significantly higher than before treatment. After treatment, IL-4, IgE and IFN-γ had no significant difference in the salt treatment and con- trol groups. Conclusion Halotherapy can reduce the patient＇s peripheral blood IL-4 and IgE, and increase IFN-γ. It shows that Halotherapy is a good non-drug therapy for the treatment of bronchial asthma

关 键 词：盐疗 支气管哮喘 IL-4 IFN-γ IGE 

分 类 号：R562.25[医药卫生—呼吸系统]