胸腺素β_4在心脏保护和修复中的作用  

Effects of Thymosin beta4 in Cardiac Protection and Repair

作　　者：汤涌[1] 黄进[1] 

机构地区：[1]南京市胸科医院心内科,南京210029

出　　处：《医学综述》2013年第3期392-394,共3页Medical Recapitulate

基　　金：南京市医学科技发展项目(YKK09147)

摘　　要：胸腺素β4在多种组织和细胞中都有表达,在心脏的发育过程中起着重要的作用,促进冠状血管的发生,诱导新生血管形成。胸腺素β4在损伤组织的再生、重构和愈合中发挥着重要的作用,促进了血管生成、内皮细胞的分化和生长,促进心肌细胞和内皮细胞的迁移,促进冠心病患者侧支循环的形成,增加心肌细胞的存活和修复,改善心脏功能。这些均显示了胸腺素β4在心肌保护和修复作用中的重要地位。The expression of thymosin beta-4 in many kinds of tissues and cells plays an important role in cardiac development,and promotes coronary development and angiogenesis.Meanwhile,thymosin beta-4 plays another important role in tissular regeneration,remodeling,healing,and promotes angiogenesis in injured tissue,and endothelial differentiation,cardiac and endothelial cells migration,collateral development in coronary artery disease,increases survival and cardiac repair,and enhances heart function,which all suggest that thymosin beta-4 is important in cardiac protection and repair.

关 键 词：胸腺素Β4 血管生成 心脏保护 修复 

分 类 号：R541[医药卫生—心血管疾病]