白芷提取物的稳定性研究  

Study on the stability of Angelica dahurica(Fisch ex. Hoffm. ) extract

作　　者：何珊珊[1] 武尉杰[1] 谭睿[1] 

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031

出　　处：《川北医学院学报》2013年第1期6-9,共4页Journal of North Sichuan Medical College

基　　金：国家自然科学基金(81173594);四川省科技支撑计划项目(2011SZ0231);中央高校基本科研业务费专项资金项目:(SWJTU11ZT26);四川省应用基础项目(2012JY0025)

摘　　要：目的:通过乙醇提取法提取白芷有效成分,由白芷提取物的紫外光谱研究白芷提取物的稳定性。方法:使用紫外分光光度计确定白芷提取物的最大吸收波长,测定其最大吸光度。结果:白芷的提取物(呋喃香豆素类化合物)的最大吸收波长为299 nm,对时间和氧化剂的稳定性较好,光照下稳定性下降,随温度升高稳定性先增加后降低,不同pH值下溶液的吸光度改变不同,金属离子可以提高呋喃香豆素类化合物的稳定性。结论:白芷的乙醇提取物应尽量避光置于碱性条件久储,其本身抗氧化性较好,加入金属离子有利于提取物的长期存放。Objective：to research the stability of the extract of Angelica dahurica （Fisch. ex. Hoffm. ）. by ultraviolet absorption change. Methods： A ultraviolet spectrophotometer was used to determine the maximum absorption wavelength and determine the big- gest spectro-photometry of the extract. Results： Storage time had no influence on the stability of the extract, but the illumination, tem- perature, pH value, oxidant, metal ion of Cu2＋ and Fe2＋ and Fe3 ＋ affect the biggest spectro - photometry of the extract. The best ex- traction process of Angelica dahurica （ Fisch. ex. Hoffm. ） was that extract tripled with 70% ethanol in a 1：5 solid-liquid rate, every time three hours. The extract of Angelica dahurica （Fisch. ex. Hoffm. ） is not stable under light, metal ion, PH value, the oxidant, the temperature , and attention should he paid to its storage. Conclusion：In order to store the extract for a longer time , the ethanol extract of Angelica is advised to be stored in a dark environment which is alkaline.

关 键 词：白芷 提取物 稳定性 

分 类 号：R284.2[医药卫生—中药学]