周围静脉与深静脉置管两种溶栓方法治疗急性下肢深静脉血栓的对照观察  

Contrast of curative effect and complications between peripheral venous thrombolysis and catheter- direct thrombolysis for acute deep venous thrombosis in lower limbs

作　　者：刘万泉[1] 张曦彤[1] 黎冶[2] 王刚[2] 王颖[1] 夏永辉[1] 梁松年[1] 徐克[1] 

机构地区：[1]中国医科大学附属第一医院放射科,沈阳110001 [2]沈阳市第五人民医院介入科

出　　处：《中华医学杂志》2013年第7期531-533,共3页National Medical Journal of China

基　　金：辽宁省教育厅创新团队项目（LT2010104）

摘　　要：目的比较周围静脉溶栓与深静脉置管溶栓治疗急性下肢深静脉血栓形成（DVT）的近期疗效与并发症，评价深静脉置管溶栓的应用价值。方法收集2008年1月至2010年12月中国医科大学附属第一医院放射科86例DVT患者，分为周围浅静脉溶栓组（A组，33例）和深静脉置管溶栓组（B组，53例），对比两组下肢消肿率、静脉通畅率及近期并发症的差异。结果两组消肿率比较（大腿A组59％±33％，B组66％±30％；小腿A组67％±31％，B组60％±30％），差异无统计学意义（P〉0．05）。静脉通畅率比较，B组（57％±23％）优于A组（38％±26％），差异有统计学意义（P〈0．05）。两组出血发生率差异无统计学意义（P〉0．05），均无症状性肺梗死发生。结论两种溶栓方法均可有效改善急性下肢DVT症状，深静脉置管溶栓静脉通畅率高，且不增加溶栓出血概率。Objective thrombosis （ DVT ） . Methods To evaluate the effects of catheter-direct thrombolysis in acute deep venous A total of 86 cases were divided into 2 groups of peripheral venous thrombolysis （group A, n = 33 ） and catheter-direct thrombolysis （group B, n = 53 ）. The curative effect of two groups was compared by swelling rate and vascular potency. Results No significant difference existed in swelling rate between two groups （ P 〉 0. 05 ）. Vascular patency rates of group B was significantly better than those of group A （P 〈0.01 ）. The incidence of bleeding had no significant difference （P 〉0. 05） and there was no asymptomatic pulmonary embolism in two groups. Conclusion Both treatments of acute DVT are effective in improving symptoms. But catheter-directed thrombolysis results in significant vascular patency rate and does not increase the risk of thrombolytic bleeding.

关 键 词：血栓形成 血栓溶解疗法 临床对照试验 

分 类 号：R543[医药卫生—心血管疾病]