磁性纳米颗粒作为基因载体的研究进展  

Research progress of magnetic nanoparticles as Gene Vector

作　　者：侯欣欣[1] 张皓[1] 张东生[1] 

机构地区：[1]东南大学医学院病理与病理生理学系,南京医学硕士研究生210009

出　　处：《医学研究生学报》2013年第2期186-189,共4页Journal of Medical Postgraduates

基　　金：国家863计划(2007AA03Z356);国家自然科学基金(30770584;81171452);江苏省自然科学基金(BK2010357)

摘　　要：作为非病毒基因载体,磁性纳米基因载体主要指无机非金属材料纳米氧化铁和铁氧体等,近年来其研究广受关注。文中对非病毒基因载体磁性纳米颗粒的种类、性质、制备方法和表面修饰进行综述,并介绍了磁性纳米基因载体介导的体内外基因转染,以及联合磁热疗与靶向治疗癌症领域的相关进展。Magnetic nano-gene mainly refers to inorganic non-metallic materials including nano ferric oxide and ferrite, etc. Recently, research causes wild public concern on magnetic nanoparticles as non-virus gene vector. The paper demonstrates the types and properties, the common preparation methods and surface modification of magnetic nanopartieles as non-virus gene carrier. And the latest application of gene transfection of magnetic nanoparticles in vitro and in vivo, combined with magnetic fluid hyperthermia（MFH） or target therapy to cancer are reviewed.

关 键 词：磁性纳米颗粒 基因载体 非病毒载体 基因治疗 

分 类 号：TQ138.11[化学工程—无机化工]