医用三氧治疗颈动脉斑块及对炎性因子影响的临床研究  

Clinical study of medical trioxyen on carotid plaque and its influence on inflammatory factor

作　　者：杨明[1] 王展航 邹志才[1] 任利民[1] 季燕[1] 阳文浩[1] 尹静[1] 谢卉[1] 付俊峰[3] 孙蕾[3] 王伟[4] 熊杰[4] 

机构地区：[1]广州中医药大学祈福医院神经内科,511495 [2]广东三九脑科医院神经内科,广州510510 [3]广州中医药大学祈福医院超声科,511495 [4]广州中医药大学祈福医院三氧中心,511495

出　　处：《中国医师进修杂志》2013年第1期1-3,共3页Chinese Journal of Postgraduates of Medicine

基　　金：广东省中医药局2010年建设中医药强省科研课题（2010442）

摘　　要：目的探讨医用三氧大自血疗法对颈动脉斑块的临床疗效以及对炎性因子的影响。方法选择2010年10月至2011年12月住院行颈动脉彩超检查提示颈动脉软斑或（和）混合斑的患者90例，按照随机数字表法分为三氧组、阿托伐他汀组和饮食组，每组30例。饮食组给予低脂饮食控制；阿托伐他汀组给予阿托伐他汀20mg，每天1次口服；三氧组给予医用三氧大自血疗法，每周2次。1个疗程为8次，共2个疗程，中间间隔3个月。检测双侧颈动脉内膜．中层厚度，斑块个数、面积、性质、纤维帽特性及超敏C反应蛋白（hs-CRP）等指标。比较三组治疗前后的颈动脉斑块Crouse积分、hs。CRP的变化。结果治疗前阿托伐他汀组、三氧组斑块Crouse积分、hs-CRP分别为（2．34±0．97）分、（4．9±4．0）mg／L和（2．35±0．63）分、（4．8±3．7）mg／L，治疗后分别为（1．80±0．59）分、（3．3±2．2）mg／L和（1．92±0．47）分、（3．4±2．0）mg／L，治疗后较治疗前明显下降，差异有统计学意义（P〈0．05）。而饮食组治疗前后的斑块Crouse积分、hs-CRP的变化差异无统计学意义（P〉0．05）。治疗后，阿托伐他汀组、三氧组与饮食组比较，斑块Crouse积分、hs-CRP明显下降，差异有统计学意义（P〈0．05）；而阿托伐他汀组与三氧组之间斑块Crouse积分、hs-CRP比较差异无统计学意义（P〉0．05）。结论医用三氧大自血疗法可调低hs-CRP水平，达到抗炎抗动脉硬化，从而逆转颈动脉斑块的作用，疗效与阿托伐他汀相当，明显优于饮食控制，可作为颈动脉斑块治疗的新途径。Objective To investigate the clinical effect of medical trioxyen major autohemotherapy （MAH） on carotid plaque and its influence on inflammatory factor. Methods Ninety patients with soft carotid plaque or （and） mixture sample diagnosed by the examination of carotid color ultrasonography from October 2010 to December 2011 were divided into three groups by random digits table method with 30 cases each. The diet group was given low-fat diet; the artorvastatin group was given 20 mg artorvastatin once a day; while the trioxyen group was treated with medical trioxyen MAH. This treatment contained two courses of treatment with an interval of three months, eight times in each course and twice a week. The carotid intima- media thickness and such indexes as the number,size,characteristics,fibrous cap and high sensitivity C-reactive protein （hs-CRP） of the plaque etc were detected. The changes of the plaque Crouse score and hs-CRP before and after treatment among three groups were compared. Results Before treatment,the plaque Crouse score of the artorvastatin group,trioxyen group and diet group was （2.34 ± 0.97）, （2.35 ± 0.63 ） and （2.34 ± 0.82） scores, respectively. While after treatment, it was （ 1.80 ± 0.59）, （ 1.92 ± 0.47） and （2.29 -e 0.71） scores, respectively. Before treatment,the hs-CRP of the artorvastatin group,trioxyen group and diet group was （4.9 ± 4.0）, （4.8 ± 3.7） and （4.8 ± 3.6） rag/L, respectively. While after treatment, it was （3.3 ± 2.2）, （3.4 ± 2.0） and （4.6 ± 2.5） mg/L, respectively. There was significant difference in the plaque Crouse score and hs-CRP in the artorvastatin group and the trioxyen group before and after treatment （P 〈0.05）;while there was no statistical significance in the diet group （P 〉0.05）. After 6 months of treatment, a remarkable slide showed in the plaque Crouse score and hs-CRP among the artorvastatin group, the trioxyen group and the diet group （P 〈 0.05）. But there was no statistical signif

关 键 词：颈动脉疾病 C反应蛋白质 医用三氧 阿托伐他汀 

分 类 号：R54[医药卫生—心血管疾病]