实时组织弹性成像技术在无创评价慢性乙型肝炎肝纤维化中的应用  

Application of real-time elastic imaging techniques in the evaluation of liver cirrhosis in patients with chronic hepatitis B

作　　者：李晓云[1] 赵夏夏[2] 焦建中 王译晗[2] 王海筠 苗英[2] 崔丽琼[2] 吉新雁[2] 

机构地区：[1]兰州军区兰州总医院,甘肃兰州730050 [2]解放军第一医院

出　　处：《西北国防医学杂志》2013年第1期5-7,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:探讨实时组织弹性成像方法在无创评价慢性乙型肝炎肝纤维化中的应用。方法:应用组织弥散定量分析软件分析98例慢性乙型肝炎后肝硬化组、100例健康者(健康对照组)的肝脏硬度,得到11个弹性图像的特征量,包括应变均值、标准差、蓝色区域%、复杂度、峰值、偏度、对比度、均等性、杂乱性、一致性、相关性。结果:健康对照组与肝硬化组弹性图像特征量的应变均值、标准差、蓝色区域%、复杂度、峰度、偏度、对比度、均等性、杂乱性、一致性、相关性分别为114.96±37.54/100.07±17.73、51.85±29.69/59.76±11.00、15.00±7.94/28.83±15.85、23.57±5.72/32.83±14.55、2.80±0.45/2.73±0.59、0.25±0.18/0.48±0.35、163.07±54.31/225.40±94.82、3.83±0.09/3.77±0.24、0.12±0.17/0.14±0.04、0.01±0.00/0.01±0.00、0.96±0.03/0.96±0.00;肝脏硬度指数1.97±0.56/2.47±1.00。肝纤维化组与健康对照组间,除相关性、一致性、均等性无统计学意义(P>0.05)外,其余各值均有统计学差异(P<0.01)。结论:实时组织弹性成像技术的组织弥散定量分析软件有助于肝脏硬度的评估,可成为无创评价慢性乙型肝炎肝硬化的有效方法。Objective：To explore the application of real -time elastic imaging techniques in the evaluation of liver fibrosis in patients with chronic hepatitis B. Methods： Liver stiffness of 98 cases of liver cirrhosis in patients with chronic hepatitis B （liver fibrosis group） and 100 volunteers （control group） were detected by color Doppler ultrasound and analyzed by the tissue dispersion quantitative analysis software. Eleven elastic characteristics of the elastography were obtained including average relative strain value （MEAN） , standard deviation of relative strain value（SD）, area ratio of low- strain region （% AREA） , complexity （COMP）, kurtosis （KURT） , skewness （ SKEW ）, contrast （ CONT ）, entropy （ ENT）, inverse different moment （ IDM ）, angular second moment （ASM）, and correlation （CORR）. Results： The MEAN, SD, % AREA, COMP, KURT, SKEW, CONT, ENT, IDM, ASM, CORR, index of liver stiffness of elastography in the control group and liver fibrosis group were 114.96 ± 37.54/100.07 ± 17.73,51.85 ± 29.69/59.76 ± 11.00,15.00 ± 7.94/28.83 ± 15.85, 23.57 ±5.72,32.83 ± 14.55,2.80±0.45/2.73 ±0.59,0.25 ±0.18/0.48 ±0.35,163.07 ±54.3/225.40 ±94.82,3.83 ±0.09/3.77 ± 0.24,0.12 ± 0.17/0.14 ± 0.04,0.01 ± 0.00/0.01 ± 0.00,0.96 ± 0.03/0.96 ± 0.00,1.97 ± 0.56/2.47 ± 1.00, respectively. There were significant difference in MEAN, SD, % AREA, COMP, KURT, SKEW, CONT, IDM and index of liver stiffness between the two groups（P 〈0.01 ）. Conclusion：The tissue dispersion quantitative analysis software is helpful in the evaluation of hepatic stiffness and would provid valid method in the evaluation of liver cirrhosis in patients with chronic hepatitis B.

关 键 词：超声波诊断 实时组织弹性成像 乙型肝炎 肝纤维化 

分 类 号：R445.1[医药卫生—影像医学与核医学]