镰形棘豆总黄酮对D-半乳糖致衰老小鼠的抗氧化实验研究  

Antioxidative effect of total flavonoids from Oxytropis falcata Bunge on aging mice induced by D-galactose

作　　者：尉丽力[1] 李茂星[1] 张泉龙[1] 邱建国[1] 

机构地区：[1]兰州军区兰州总医院全军高原环境损伤防治重点实验室,甘肃兰州730050

出　　处：《西北国防医学杂志》2013年第1期8-10,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：甘肃省科技攻关项目(1011FKDA131);全军医药卫生"十一五"课题面上项目(06MB100);南京军区医药卫生科研课题(06MA-95)

摘　　要：目的:研究镰形棘豆总黄酮提取物对D-半乳糖致亚急性衰老小鼠的抗氧化作用。方法:腹腔注射D-半乳糖建立衰老小鼠模型,镰形棘豆总黄酮水溶液500、200、100 mg/kg分别连续灌胃70 d后,测定各组小鼠血浆、心脏和肝脏中的超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽(GSH)的含量。结果:与模型组比较,低剂量能显著升高血浆和肝脏中SOD(P<0.05),降低心脏和肝脏中的MDA(P<0.01),升高心脏和肝脏中的GSH(P<0.01或P<0.05)。结论:镰形棘豆总黄酮具有明显的抗氧化衰老作用。Objective ： To study the antioxidative effect of total flavonoids from Oxytropis falcata Bunge （TFOF） on aging mice induced by D - galactose. Methods ： The ageing mice model was established by injection of D - ga- lactose. The mice were orally given TFOF with doses of 500 mg/kg, 200 mg/kg, and 100 mg/kg, respectively. All mice were treated for seventy days, and the content of SOD, MDA and GSH in blood, heart and liver tissue were determined. Results： Compared with aging model, the low dose of TFOF could significantly raise the content of SOD in blood and liver tissue （P 〈 0.05 ）, decrease the level of MDA in heart and liver tissue （P 〈 0.01 ） and raise the level of GSH in heart and liver tissue （ P 〈 0.01 or P 〈 0.05 ）. Conclusion ： The TFOF exhibits significant antioxidation activity.

关 键 词：镰形棘豆 总黄酮 抗氧化 衰老 D-半乳糖 

分 类 号：R285.5[医药卫生—中药学]