埃他卡林片对低氧性肺动脉高压血清酶活性的影响  

Effect of Iptkalim on serum enzyme activity in patients with hypoxic pulmonary hypertension

作　　者：崔建华 高亮 杨海军 张东祥[2] 肖忠海[2] 李彬 马广全 汪海[2] 

机构地区：[1]解放军18医院全军高山病防治研究中心,新疆叶城844900 [2]军事医学科学院卫生学环境医学研究所

出　　处：《西北国防医学杂志》2013年第1期18-20,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：国家重大新药保密专项(2008ZXJ09004-018/50);高原医学教育部重点实验室资助项目(2011JSGY05);军区"十一五"攻关项目(08G081)

摘　　要：目的:研究埃他卡林对缺氧性肺动脉高压(HPH)患者血清酶活性的影响。方法:在海拔5000 m以上高原,将110名HPH患者随机分为埃他卡林治疗组(实验组,n=74)和安慰剂对照组(对照组,n=36),治疗前、治疗6个月后分别采血检测丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、r-谷氨酰转肽酶(r-GT)、肌酸激酶(CK)和乳酸脱氢酶(LDH)活性。结果:服药后组内实验组较对照组ALT、AST、r-GT、CK、LDH均降低,差异有统计学意义(P<0.05);服药前无统计学差异(P>0.05)。服药后较服药前实验组和对照组组间比较均增多,有非常显著性差异(P<0.01)。结论:埃他卡林对低氧造成应激损伤的心肌细胞具有明显的保护作用,其保护作用与线粒体膜和细胞膜的KATP通道激活有关。Objective：To explore the effect of Iptkalim on serum enzyme activity in patients with hypoxic pulmonary hypertension （HPH）. Methods： A total of 110 HPH patients living in high altitude area （above 5000 m） were randomly divided into Iptkalim group （n = 74） and placebo group （n = 36）. The serum ALT, AST, r- GT, CK and LDH levels were detected before therapy and after treatment of 6 months. Results： There was no difference before administration of medicine （ P 〉 0.05 ）, there were obvious differences in the serum ALT, AST, r - GT, CK and LDH levels between the two groups after treatment （P 〈 0.05 ） . Compared with groups before administration of medicine, the levels of the serum enzymes were significantly increased in both groups after treament （ P 〈 0.01 ）. Conclusion： The Iptkalim can protect myocardial cells injured by hypoxia, which may be related with the KATP channel activation of mitochondrial membrane and cell membrane.

关 键 词：高原 缺氧性肺动脉高压 埃他卡林 血清酶 

分 类 号：R96[医药卫生—药理学]