大鼠脑底动脉肾上腺素能神经分布的免疫组织化学研究  

Distribution of Adrenergic Nerve on Cerebral Arterys in Rats

作　　者：薛国勇[1] 林雪群[1] 

机构地区：[1]南昌大学医学院解剖教研室,南昌330006

出　　处：《南昌大学学报（医学版）》2012年第11期12-14,共3页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨大鼠脑底动脉肾上腺素能神经的分布方式,为深入阐明脑底动脉神经与脑血管疾病之间的关系提供形态学基础资料。方法选择Wistar大鼠10只,应用免疫组织化学ABC法,对大鼠脑底动脉(大脑前动脉、大脑中动脉、大脑后动脉、基底动脉)肾上腺素能神经分布进行观察。结果正常大鼠大脑前动脉、大脑中动脉、大脑后动脉、基底动脉均可见棕褐色、细线状的免疫反应阳性纤维,其密度分别为(17.4±3.23)、(15.45±3.62)、(12.72±3.25)和(12.35±2.75)条.mm-1。各脑底动脉分支近端有较密集的肾上腺素能神经,从脑底动脉吻侧至尾侧肾上腺素能神经密度依次递减。结论大鼠脑底动脉有明显肾上腺素能神经纤维,其与鼠脑血管活动和脑痉挛的发生和发展有重要关系。Objective To explore the distribution of adrenergic nerve on cerebral arterys in rats.further clarify the relationship between cerebral artery in neurological and cerebrovascular diseases on morphological basis.Methods Ten Wistar rats density of adrenergic nerve innervating on the arteries of the circle of willis（anterior cerebral artery,middle cerebral artery,posterior cerebral artery,basilar artery） were studied with immunoperoxidase ABC technique.Results The immunopoisitive fibers with the brown linear structures were observed on the arteries of the circle of willis in rats.Their density were（17.4±3.23）,（15.45±3.62）,（12.72±3.25） and（12.35±2.75）strips·mm-1.Proximal of the various cerebral artery branch have intensive adrenergic nerve,adrenaline nerve density in descending order from the base of the brain arteries rostral than caudal.Conclusion Cerebral arteries in rats have obviously adrenergic nerve fibers.It suggests that the adrenergic nerve might play an important role in the maintenance and development of cerebral vasospasm.

关 键 词：肾上腺素能神经 脑底动脉 免疫组织化学 动物 实验 大鼠 

分 类 号：R332[医药卫生—人体生理学]